A Diverse and Versatile Regiospecific Synthesis of Tetrasubstituted Alkylsulfanylimidazoles as p38α Mitogen-Activated Protein Kinase Inhibitors

An alternative strategy for the synthesis of 1-aryl- and 1-alkyl-2-methylsulfanyl-4-(4-fluorophenyl)-5-(pyridin-4-yl)imidazoles as potential p38α mitogen-activated protein kinase inhibitors is reported. The regioselective N-substitution of the imidazole ring was achieved by treatment of α-aminoketon...

Descripción completa

Detalles Bibliográficos
Autores principales: Ansideri, Francesco, Andreev, Stanislav, Kuhn, Annette, Albrecht, Wolfgang, Laufer, Stefan A., Koch, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017033/
https://www.ncbi.nlm.nih.gov/pubmed/29361698
http://dx.doi.org/10.3390/molecules23010221

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017033/
https://www.ncbi.nlm.nih.gov/pubmed/29361698
http://dx.doi.org/10.3390/molecules23010221

Ejemplares similares