An Efficient Chemoenzymatic Approach towards the Synthesis of Rugulactone

Rugulactone is a natural product isolated from the plant Cryptocarya rugulosa. It has shown very important biological activity as an inhibitor of the nuclear factor κB (NF-κB) activation pathway. A new chemoenzymatic approach towards the synthesis of rugulactone is presented here. The chirality, ind...

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Autores principales: Tyrikos-Ergas, Theodore, Giannopoulos, Vasileios, Smonou, Ioulia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017073/
https://www.ncbi.nlm.nih.gov/pubmed/29534553
http://dx.doi.org/10.3390/molecules23030640
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author Tyrikos-Ergas, Theodore
Giannopoulos, Vasileios
Smonou, Ioulia
author_facet Tyrikos-Ergas, Theodore
Giannopoulos, Vasileios
Smonou, Ioulia
author_sort Tyrikos-Ergas, Theodore
collection PubMed
description Rugulactone is a natural product isolated from the plant Cryptocarya rugulosa. It has shown very important biological activity as an inhibitor of the nuclear factor κB (NF-κB) activation pathway. A new chemoenzymatic approach towards the synthesis of rugulactone is presented here. The chirality, induced to the key intermediate by a stereoselective enzymatic reduction utilizing NADPH-dependent ketoreductase, is described in detail.
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spelling pubmed-60170732018-11-13 An Efficient Chemoenzymatic Approach towards the Synthesis of Rugulactone Tyrikos-Ergas, Theodore Giannopoulos, Vasileios Smonou, Ioulia Molecules Article Rugulactone is a natural product isolated from the plant Cryptocarya rugulosa. It has shown very important biological activity as an inhibitor of the nuclear factor κB (NF-κB) activation pathway. A new chemoenzymatic approach towards the synthesis of rugulactone is presented here. The chirality, induced to the key intermediate by a stereoselective enzymatic reduction utilizing NADPH-dependent ketoreductase, is described in detail. MDPI 2018-03-12 /pmc/articles/PMC6017073/ /pubmed/29534553 http://dx.doi.org/10.3390/molecules23030640 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tyrikos-Ergas, Theodore
Giannopoulos, Vasileios
Smonou, Ioulia
An Efficient Chemoenzymatic Approach towards the Synthesis of Rugulactone
title An Efficient Chemoenzymatic Approach towards the Synthesis of Rugulactone
title_full An Efficient Chemoenzymatic Approach towards the Synthesis of Rugulactone
title_fullStr An Efficient Chemoenzymatic Approach towards the Synthesis of Rugulactone
title_full_unstemmed An Efficient Chemoenzymatic Approach towards the Synthesis of Rugulactone
title_short An Efficient Chemoenzymatic Approach towards the Synthesis of Rugulactone
title_sort efficient chemoenzymatic approach towards the synthesis of rugulactone
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017073/
https://www.ncbi.nlm.nih.gov/pubmed/29534553
http://dx.doi.org/10.3390/molecules23030640
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