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Action of Phytochemicals on Insulin Signaling Pathways Accelerating Glucose Transporter (GLUT4) Protein Translocation

Diabetes is associated with obesity, generally accompanied by a chronic state of oxidative stress and redox imbalances which are implicated in the progression of micro- and macro-complications like heart disease, stroke, dementia, cancer, kidney failure and blindness. All these complications rise pr...

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Autores principales: Sayem, Abu Sadat Md, Arya, Aditya, Karimian, Hamed, Krishnasamy, Narendiran, Ashok Hasamnis, Ameya, Hossain, Chowdhury Faiz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017132/
https://www.ncbi.nlm.nih.gov/pubmed/29382104
http://dx.doi.org/10.3390/molecules23020258
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author Sayem, Abu Sadat Md
Arya, Aditya
Karimian, Hamed
Krishnasamy, Narendiran
Ashok Hasamnis, Ameya
Hossain, Chowdhury Faiz
author_facet Sayem, Abu Sadat Md
Arya, Aditya
Karimian, Hamed
Krishnasamy, Narendiran
Ashok Hasamnis, Ameya
Hossain, Chowdhury Faiz
author_sort Sayem, Abu Sadat Md
collection PubMed
description Diabetes is associated with obesity, generally accompanied by a chronic state of oxidative stress and redox imbalances which are implicated in the progression of micro- and macro-complications like heart disease, stroke, dementia, cancer, kidney failure and blindness. All these complications rise primarily due to consistent high blood glucose levels. Insulin and glucagon help to maintain the homeostasis of glucose and lipids through signaling cascades. Pancreatic hormones stimulate translocation of the glucose transporter isoform 4 (GLUT4) from an intracellular location to the cell surface and facilitate the rapid insulin-dependent storage of glucose in muscle and fat cells. Malfunction in glucose uptake mechanisms, primarily contribute to insulin resistance in type 2 diabetes. Plant secondary metabolites, commonly known as phytochemicals, are reported to have great benefits in the management of type 2 diabetes. The role of phytochemicals and their action on insulin signaling pathways through stimulation of GLUT4 translocation is crucial to understand the pathogenesis of this disease in the management process. This review will summarize the effects of phytochemicals and their action on insulin signaling pathways accelerating GLUT4 translocation based on the current literature.
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spelling pubmed-60171322018-11-13 Action of Phytochemicals on Insulin Signaling Pathways Accelerating Glucose Transporter (GLUT4) Protein Translocation Sayem, Abu Sadat Md Arya, Aditya Karimian, Hamed Krishnasamy, Narendiran Ashok Hasamnis, Ameya Hossain, Chowdhury Faiz Molecules Review Diabetes is associated with obesity, generally accompanied by a chronic state of oxidative stress and redox imbalances which are implicated in the progression of micro- and macro-complications like heart disease, stroke, dementia, cancer, kidney failure and blindness. All these complications rise primarily due to consistent high blood glucose levels. Insulin and glucagon help to maintain the homeostasis of glucose and lipids through signaling cascades. Pancreatic hormones stimulate translocation of the glucose transporter isoform 4 (GLUT4) from an intracellular location to the cell surface and facilitate the rapid insulin-dependent storage of glucose in muscle and fat cells. Malfunction in glucose uptake mechanisms, primarily contribute to insulin resistance in type 2 diabetes. Plant secondary metabolites, commonly known as phytochemicals, are reported to have great benefits in the management of type 2 diabetes. The role of phytochemicals and their action on insulin signaling pathways through stimulation of GLUT4 translocation is crucial to understand the pathogenesis of this disease in the management process. This review will summarize the effects of phytochemicals and their action on insulin signaling pathways accelerating GLUT4 translocation based on the current literature. MDPI 2018-01-28 /pmc/articles/PMC6017132/ /pubmed/29382104 http://dx.doi.org/10.3390/molecules23020258 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sayem, Abu Sadat Md
Arya, Aditya
Karimian, Hamed
Krishnasamy, Narendiran
Ashok Hasamnis, Ameya
Hossain, Chowdhury Faiz
Action of Phytochemicals on Insulin Signaling Pathways Accelerating Glucose Transporter (GLUT4) Protein Translocation
title Action of Phytochemicals on Insulin Signaling Pathways Accelerating Glucose Transporter (GLUT4) Protein Translocation
title_full Action of Phytochemicals on Insulin Signaling Pathways Accelerating Glucose Transporter (GLUT4) Protein Translocation
title_fullStr Action of Phytochemicals on Insulin Signaling Pathways Accelerating Glucose Transporter (GLUT4) Protein Translocation
title_full_unstemmed Action of Phytochemicals on Insulin Signaling Pathways Accelerating Glucose Transporter (GLUT4) Protein Translocation
title_short Action of Phytochemicals on Insulin Signaling Pathways Accelerating Glucose Transporter (GLUT4) Protein Translocation
title_sort action of phytochemicals on insulin signaling pathways accelerating glucose transporter (glut4) protein translocation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017132/
https://www.ncbi.nlm.nih.gov/pubmed/29382104
http://dx.doi.org/10.3390/molecules23020258
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