Triterpenoid Saponins from Anemone rivularis var. Flore-Minore and Their Anti-Proliferative Activity on HSC-T6 Cells

Five previously undescribed triterpenoid saponins (1–5), along with eight known ones (6–13), were isolated from the whole plants of Anemone rivularis var. flore-minore. Their structures were clarified by extensive spectroscopic data and chemical evidence. For the first time, the lupane-type saponins...

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Detalles Bibliográficos
Autores principales: Wang, Xiao-Yang, Gao, Hui, Xie, Xiao-Jie, Jurhiin, Jirimubatu, Zhang, Mu-Zi-He, Zhou, Yan-Ping, Liu, Rui, Ning, Meng, Han, Jin, Tang, Hai-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017197/
https://www.ncbi.nlm.nih.gov/pubmed/29473864
http://dx.doi.org/10.3390/molecules23020491
Descripción
Sumario:Five previously undescribed triterpenoid saponins (1–5), along with eight known ones (6–13), were isolated from the whole plants of Anemone rivularis var. flore-minore. Their structures were clarified by extensive spectroscopic data and chemical evidence. For the first time, the lupane-type saponins (3 and 12) were reported from the Anemone genus. The anti-proliferative activity of all isolated saponins was evaluated on hepatic stellate cells (HSC-T6). Saponins 12 and 13, which possess more monosaccharides than the others, displayed potent anti-proliferative activity, with IC(50) values of 18.21 and 15.56 μM, respectively.

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