Triterpenoid Saponins from Anemone rivularis var. Flore-Minore and Their Anti-Proliferative Activity on HSC-T6 Cells

Five previously undescribed triterpenoid saponins (1–5), along with eight known ones (6–13), were isolated from the whole plants of Anemone rivularis var. flore-minore. Their structures were clarified by extensive spectroscopic data and chemical evidence. For the first time, the lupane-type saponins...

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Autores principales: Wang, Xiao-Yang, Gao, Hui, Xie, Xiao-Jie, Jurhiin, Jirimubatu, Zhang, Mu-Zi-He, Zhou, Yan-Ping, Liu, Rui, Ning, Meng, Han, Jin, Tang, Hai-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017197/
https://www.ncbi.nlm.nih.gov/pubmed/29473864
http://dx.doi.org/10.3390/molecules23020491
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author Wang, Xiao-Yang
Gao, Hui
Xie, Xiao-Jie
Jurhiin, Jirimubatu
Zhang, Mu-Zi-He
Zhou, Yan-Ping
Liu, Rui
Ning, Meng
Han, Jin
Tang, Hai-Feng
author_facet Wang, Xiao-Yang
Gao, Hui
Xie, Xiao-Jie
Jurhiin, Jirimubatu
Zhang, Mu-Zi-He
Zhou, Yan-Ping
Liu, Rui
Ning, Meng
Han, Jin
Tang, Hai-Feng
author_sort Wang, Xiao-Yang
collection PubMed
description Five previously undescribed triterpenoid saponins (1–5), along with eight known ones (6–13), were isolated from the whole plants of Anemone rivularis var. flore-minore. Their structures were clarified by extensive spectroscopic data and chemical evidence. For the first time, the lupane-type saponins (3 and 12) were reported from the Anemone genus. The anti-proliferative activity of all isolated saponins was evaluated on hepatic stellate cells (HSC-T6). Saponins 12 and 13, which possess more monosaccharides than the others, displayed potent anti-proliferative activity, with IC(50) values of 18.21 and 15.56 μM, respectively.
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spelling pubmed-60171972018-11-13 Triterpenoid Saponins from Anemone rivularis var. Flore-Minore and Their Anti-Proliferative Activity on HSC-T6 Cells Wang, Xiao-Yang Gao, Hui Xie, Xiao-Jie Jurhiin, Jirimubatu Zhang, Mu-Zi-He Zhou, Yan-Ping Liu, Rui Ning, Meng Han, Jin Tang, Hai-Feng Molecules Article Five previously undescribed triterpenoid saponins (1–5), along with eight known ones (6–13), were isolated from the whole plants of Anemone rivularis var. flore-minore. Their structures were clarified by extensive spectroscopic data and chemical evidence. For the first time, the lupane-type saponins (3 and 12) were reported from the Anemone genus. The anti-proliferative activity of all isolated saponins was evaluated on hepatic stellate cells (HSC-T6). Saponins 12 and 13, which possess more monosaccharides than the others, displayed potent anti-proliferative activity, with IC(50) values of 18.21 and 15.56 μM, respectively. MDPI 2018-02-23 /pmc/articles/PMC6017197/ /pubmed/29473864 http://dx.doi.org/10.3390/molecules23020491 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wang, Xiao-Yang
Gao, Hui
Xie, Xiao-Jie
Jurhiin, Jirimubatu
Zhang, Mu-Zi-He
Zhou, Yan-Ping
Liu, Rui
Ning, Meng
Han, Jin
Tang, Hai-Feng
Triterpenoid Saponins from Anemone rivularis var. Flore-Minore and Their Anti-Proliferative Activity on HSC-T6 Cells
title Triterpenoid Saponins from Anemone rivularis var. Flore-Minore and Their Anti-Proliferative Activity on HSC-T6 Cells
title_full Triterpenoid Saponins from Anemone rivularis var. Flore-Minore and Their Anti-Proliferative Activity on HSC-T6 Cells
title_fullStr Triterpenoid Saponins from Anemone rivularis var. Flore-Minore and Their Anti-Proliferative Activity on HSC-T6 Cells
title_full_unstemmed Triterpenoid Saponins from Anemone rivularis var. Flore-Minore and Their Anti-Proliferative Activity on HSC-T6 Cells
title_short Triterpenoid Saponins from Anemone rivularis var. Flore-Minore and Their Anti-Proliferative Activity on HSC-T6 Cells
title_sort triterpenoid saponins from anemone rivularis var. flore-minore and their anti-proliferative activity on hsc-t6 cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017197/
https://www.ncbi.nlm.nih.gov/pubmed/29473864
http://dx.doi.org/10.3390/molecules23020491
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