Terretonin N: A New Meroterpenoid from Nocardiopsis sp.

Terretonin N (1), a new highly oxygenated and unique tetracyclic 6-hydroxymeroterpenoid, was isolated together with seven known compounds from the ethyl acetate extract of a solid-state fermented culture of Nocardiopsis sp. Their structures were elucidated by spectroscopic analysis. The structure an...

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Detalles Bibliográficos
Autores principales: Hamed, Abdelaaty, Abdel-Razek, Ahmed S., Frese, Marcel, Stammler, Hans Georg, El-Haddad, Atef F., Ibrahim, Tarek M. A., Sewald, Norbert, Shaaban, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017310/
https://www.ncbi.nlm.nih.gov/pubmed/29385078
http://dx.doi.org/10.3390/molecules23020299
Descripción
Sumario:Terretonin N (1), a new highly oxygenated and unique tetracyclic 6-hydroxymeroterpenoid, was isolated together with seven known compounds from the ethyl acetate extract of a solid-state fermented culture of Nocardiopsis sp. Their structures were elucidated by spectroscopic analysis. The structure and absolute configuration of 1 were unambiguously determined by X-ray crystallography. The isolation and taxonomic characterization of Nocardiopsis sp. is reported. The antimicrobial activity and cytotoxicity of the strain extract and compound 1 were studied using different microorganisms and a cervix carcinoma cell line, respectively.

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