Terretonin N: A New Meroterpenoid from Nocardiopsis sp.

Terretonin N (1), a new highly oxygenated and unique tetracyclic 6-hydroxymeroterpenoid, was isolated together with seven known compounds from the ethyl acetate extract of a solid-state fermented culture of Nocardiopsis sp. Their structures were elucidated by spectroscopic analysis. The structure an...

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Autores principales: Hamed, Abdelaaty, Abdel-Razek, Ahmed S., Frese, Marcel, Stammler, Hans Georg, El-Haddad, Atef F., Ibrahim, Tarek M. A., Sewald, Norbert, Shaaban, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017310/
https://www.ncbi.nlm.nih.gov/pubmed/29385078
http://dx.doi.org/10.3390/molecules23020299
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author Hamed, Abdelaaty
Abdel-Razek, Ahmed S.
Frese, Marcel
Stammler, Hans Georg
El-Haddad, Atef F.
Ibrahim, Tarek M. A.
Sewald, Norbert
Shaaban, Mohamed
author_facet Hamed, Abdelaaty
Abdel-Razek, Ahmed S.
Frese, Marcel
Stammler, Hans Georg
El-Haddad, Atef F.
Ibrahim, Tarek M. A.
Sewald, Norbert
Shaaban, Mohamed
author_sort Hamed, Abdelaaty
collection PubMed
description Terretonin N (1), a new highly oxygenated and unique tetracyclic 6-hydroxymeroterpenoid, was isolated together with seven known compounds from the ethyl acetate extract of a solid-state fermented culture of Nocardiopsis sp. Their structures were elucidated by spectroscopic analysis. The structure and absolute configuration of 1 were unambiguously determined by X-ray crystallography. The isolation and taxonomic characterization of Nocardiopsis sp. is reported. The antimicrobial activity and cytotoxicity of the strain extract and compound 1 were studied using different microorganisms and a cervix carcinoma cell line, respectively.
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spelling pubmed-60173102018-11-13 Terretonin N: A New Meroterpenoid from Nocardiopsis sp. Hamed, Abdelaaty Abdel-Razek, Ahmed S. Frese, Marcel Stammler, Hans Georg El-Haddad, Atef F. Ibrahim, Tarek M. A. Sewald, Norbert Shaaban, Mohamed Molecules Article Terretonin N (1), a new highly oxygenated and unique tetracyclic 6-hydroxymeroterpenoid, was isolated together with seven known compounds from the ethyl acetate extract of a solid-state fermented culture of Nocardiopsis sp. Their structures were elucidated by spectroscopic analysis. The structure and absolute configuration of 1 were unambiguously determined by X-ray crystallography. The isolation and taxonomic characterization of Nocardiopsis sp. is reported. The antimicrobial activity and cytotoxicity of the strain extract and compound 1 were studied using different microorganisms and a cervix carcinoma cell line, respectively. MDPI 2018-01-31 /pmc/articles/PMC6017310/ /pubmed/29385078 http://dx.doi.org/10.3390/molecules23020299 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hamed, Abdelaaty
Abdel-Razek, Ahmed S.
Frese, Marcel
Stammler, Hans Georg
El-Haddad, Atef F.
Ibrahim, Tarek M. A.
Sewald, Norbert
Shaaban, Mohamed
Terretonin N: A New Meroterpenoid from Nocardiopsis sp.
title Terretonin N: A New Meroterpenoid from Nocardiopsis sp.
title_full Terretonin N: A New Meroterpenoid from Nocardiopsis sp.
title_fullStr Terretonin N: A New Meroterpenoid from Nocardiopsis sp.
title_full_unstemmed Terretonin N: A New Meroterpenoid from Nocardiopsis sp.
title_short Terretonin N: A New Meroterpenoid from Nocardiopsis sp.
title_sort terretonin n: a new meroterpenoid from nocardiopsis sp.
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017310/
https://www.ncbi.nlm.nih.gov/pubmed/29385078
http://dx.doi.org/10.3390/molecules23020299
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