Cargando…

Lupane Triterpenes from the Leaves of Acanthopanax gracilistylus

The phytochemical study on the leaves of Acanthopanax gracilistylus (Araliaceae) resulted in the discovery of a new lupane-triterpene compound, acangraciligenin S (1), and a new lupane-triterpene glycoside, acangraciliside S (2), as well as two known ones, 3α,11α-dihydroxy-lup-20(29)-en-23,28-dioic...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Xiao-Jun, Zou, Qin-Peng, Wang, Xiang, Kim, Kwan-Woo, Lu, Mao-Fang, Ko, Sung-Kwon, Yook, Chang-Soo, Kim, Youn-Chul, Liu, Xiang-Qian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017332/
https://www.ncbi.nlm.nih.gov/pubmed/29301264
http://dx.doi.org/10.3390/molecules23010087
_version_ 1783334725200379904
author Li, Xiao-Jun
Zou, Qin-Peng
Wang, Xiang
Kim, Kwan-Woo
Lu, Mao-Fang
Ko, Sung-Kwon
Yook, Chang-Soo
Kim, Youn-Chul
Liu, Xiang-Qian
author_facet Li, Xiao-Jun
Zou, Qin-Peng
Wang, Xiang
Kim, Kwan-Woo
Lu, Mao-Fang
Ko, Sung-Kwon
Yook, Chang-Soo
Kim, Youn-Chul
Liu, Xiang-Qian
author_sort Li, Xiao-Jun
collection PubMed
description The phytochemical study on the leaves of Acanthopanax gracilistylus (Araliaceae) resulted in the discovery of a new lupane-triterpene compound, acangraciligenin S (1), and a new lupane-triterpene glycoside, acangraciliside S (2), as well as two known ones, 3α,11α-dihydroxy-lup-20(29)-en-23,28-dioic acid (3) and acankoreoside C (4). Their chemical structures were elucidated by mass, 1D- and 2D-nuclear magnetic resonance (NMR) spectroscopy. The chemical structures of the new compounds 1 and 2 were determined to be 1β,3α-dihydroxy-lup-20(29)-en-23, 28-dioic acid and 1β,3α-dihydroxy-lup-20(29)-en-23,28-dioic acid 28-O-[α-l-rhamnopyranosyl-(1→4)-β-d-glucopyranosyl-(1→6)-β-d-glucopyranosyl] ester, respectively. The anti-neuroinflammatory activity of the selective compounds, 1 and 3, were evaluated with lipopolysaccharide (LPS)-induced BV2 microglia. The tested compounds showed moderate inhibitory effect of nitric oxide (NO) production.
format Online
Article
Text
id pubmed-6017332
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-60173322018-11-13 Lupane Triterpenes from the Leaves of Acanthopanax gracilistylus Li, Xiao-Jun Zou, Qin-Peng Wang, Xiang Kim, Kwan-Woo Lu, Mao-Fang Ko, Sung-Kwon Yook, Chang-Soo Kim, Youn-Chul Liu, Xiang-Qian Molecules Article The phytochemical study on the leaves of Acanthopanax gracilistylus (Araliaceae) resulted in the discovery of a new lupane-triterpene compound, acangraciligenin S (1), and a new lupane-triterpene glycoside, acangraciliside S (2), as well as two known ones, 3α,11α-dihydroxy-lup-20(29)-en-23,28-dioic acid (3) and acankoreoside C (4). Their chemical structures were elucidated by mass, 1D- and 2D-nuclear magnetic resonance (NMR) spectroscopy. The chemical structures of the new compounds 1 and 2 were determined to be 1β,3α-dihydroxy-lup-20(29)-en-23, 28-dioic acid and 1β,3α-dihydroxy-lup-20(29)-en-23,28-dioic acid 28-O-[α-l-rhamnopyranosyl-(1→4)-β-d-glucopyranosyl-(1→6)-β-d-glucopyranosyl] ester, respectively. The anti-neuroinflammatory activity of the selective compounds, 1 and 3, were evaluated with lipopolysaccharide (LPS)-induced BV2 microglia. The tested compounds showed moderate inhibitory effect of nitric oxide (NO) production. MDPI 2018-01-01 /pmc/articles/PMC6017332/ /pubmed/29301264 http://dx.doi.org/10.3390/molecules23010087 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Li, Xiao-Jun
Zou, Qin-Peng
Wang, Xiang
Kim, Kwan-Woo
Lu, Mao-Fang
Ko, Sung-Kwon
Yook, Chang-Soo
Kim, Youn-Chul
Liu, Xiang-Qian
Lupane Triterpenes from the Leaves of Acanthopanax gracilistylus
title Lupane Triterpenes from the Leaves of Acanthopanax gracilistylus
title_full Lupane Triterpenes from the Leaves of Acanthopanax gracilistylus
title_fullStr Lupane Triterpenes from the Leaves of Acanthopanax gracilistylus
title_full_unstemmed Lupane Triterpenes from the Leaves of Acanthopanax gracilistylus
title_short Lupane Triterpenes from the Leaves of Acanthopanax gracilistylus
title_sort lupane triterpenes from the leaves of acanthopanax gracilistylus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017332/
https://www.ncbi.nlm.nih.gov/pubmed/29301264
http://dx.doi.org/10.3390/molecules23010087
work_keys_str_mv AT lixiaojun lupanetriterpenesfromtheleavesofacanthopanaxgracilistylus
AT zouqinpeng lupanetriterpenesfromtheleavesofacanthopanaxgracilistylus
AT wangxiang lupanetriterpenesfromtheleavesofacanthopanaxgracilistylus
AT kimkwanwoo lupanetriterpenesfromtheleavesofacanthopanaxgracilistylus
AT lumaofang lupanetriterpenesfromtheleavesofacanthopanaxgracilistylus
AT kosungkwon lupanetriterpenesfromtheleavesofacanthopanaxgracilistylus
AT yookchangsoo lupanetriterpenesfromtheleavesofacanthopanaxgracilistylus
AT kimyounchul lupanetriterpenesfromtheleavesofacanthopanaxgracilistylus
AT liuxiangqian lupanetriterpenesfromtheleavesofacanthopanaxgracilistylus