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Lupane Triterpenes from the Leaves of Acanthopanax gracilistylus
The phytochemical study on the leaves of Acanthopanax gracilistylus (Araliaceae) resulted in the discovery of a new lupane-triterpene compound, acangraciligenin S (1), and a new lupane-triterpene glycoside, acangraciliside S (2), as well as two known ones, 3α,11α-dihydroxy-lup-20(29)-en-23,28-dioic...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017332/ https://www.ncbi.nlm.nih.gov/pubmed/29301264 http://dx.doi.org/10.3390/molecules23010087 |
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author | Li, Xiao-Jun Zou, Qin-Peng Wang, Xiang Kim, Kwan-Woo Lu, Mao-Fang Ko, Sung-Kwon Yook, Chang-Soo Kim, Youn-Chul Liu, Xiang-Qian |
author_facet | Li, Xiao-Jun Zou, Qin-Peng Wang, Xiang Kim, Kwan-Woo Lu, Mao-Fang Ko, Sung-Kwon Yook, Chang-Soo Kim, Youn-Chul Liu, Xiang-Qian |
author_sort | Li, Xiao-Jun |
collection | PubMed |
description | The phytochemical study on the leaves of Acanthopanax gracilistylus (Araliaceae) resulted in the discovery of a new lupane-triterpene compound, acangraciligenin S (1), and a new lupane-triterpene glycoside, acangraciliside S (2), as well as two known ones, 3α,11α-dihydroxy-lup-20(29)-en-23,28-dioic acid (3) and acankoreoside C (4). Their chemical structures were elucidated by mass, 1D- and 2D-nuclear magnetic resonance (NMR) spectroscopy. The chemical structures of the new compounds 1 and 2 were determined to be 1β,3α-dihydroxy-lup-20(29)-en-23, 28-dioic acid and 1β,3α-dihydroxy-lup-20(29)-en-23,28-dioic acid 28-O-[α-l-rhamnopyranosyl-(1→4)-β-d-glucopyranosyl-(1→6)-β-d-glucopyranosyl] ester, respectively. The anti-neuroinflammatory activity of the selective compounds, 1 and 3, were evaluated with lipopolysaccharide (LPS)-induced BV2 microglia. The tested compounds showed moderate inhibitory effect of nitric oxide (NO) production. |
format | Online Article Text |
id | pubmed-6017332 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-60173322018-11-13 Lupane Triterpenes from the Leaves of Acanthopanax gracilistylus Li, Xiao-Jun Zou, Qin-Peng Wang, Xiang Kim, Kwan-Woo Lu, Mao-Fang Ko, Sung-Kwon Yook, Chang-Soo Kim, Youn-Chul Liu, Xiang-Qian Molecules Article The phytochemical study on the leaves of Acanthopanax gracilistylus (Araliaceae) resulted in the discovery of a new lupane-triterpene compound, acangraciligenin S (1), and a new lupane-triterpene glycoside, acangraciliside S (2), as well as two known ones, 3α,11α-dihydroxy-lup-20(29)-en-23,28-dioic acid (3) and acankoreoside C (4). Their chemical structures were elucidated by mass, 1D- and 2D-nuclear magnetic resonance (NMR) spectroscopy. The chemical structures of the new compounds 1 and 2 were determined to be 1β,3α-dihydroxy-lup-20(29)-en-23, 28-dioic acid and 1β,3α-dihydroxy-lup-20(29)-en-23,28-dioic acid 28-O-[α-l-rhamnopyranosyl-(1→4)-β-d-glucopyranosyl-(1→6)-β-d-glucopyranosyl] ester, respectively. The anti-neuroinflammatory activity of the selective compounds, 1 and 3, were evaluated with lipopolysaccharide (LPS)-induced BV2 microglia. The tested compounds showed moderate inhibitory effect of nitric oxide (NO) production. MDPI 2018-01-01 /pmc/articles/PMC6017332/ /pubmed/29301264 http://dx.doi.org/10.3390/molecules23010087 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Li, Xiao-Jun Zou, Qin-Peng Wang, Xiang Kim, Kwan-Woo Lu, Mao-Fang Ko, Sung-Kwon Yook, Chang-Soo Kim, Youn-Chul Liu, Xiang-Qian Lupane Triterpenes from the Leaves of Acanthopanax gracilistylus |
title | Lupane Triterpenes from the Leaves of Acanthopanax
gracilistylus |
title_full | Lupane Triterpenes from the Leaves of Acanthopanax
gracilistylus |
title_fullStr | Lupane Triterpenes from the Leaves of Acanthopanax
gracilistylus |
title_full_unstemmed | Lupane Triterpenes from the Leaves of Acanthopanax
gracilistylus |
title_short | Lupane Triterpenes from the Leaves of Acanthopanax
gracilistylus |
title_sort | lupane triterpenes from the leaves of acanthopanax
gracilistylus |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017332/ https://www.ncbi.nlm.nih.gov/pubmed/29301264 http://dx.doi.org/10.3390/molecules23010087 |
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