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Effect of Pinocembrin Isolated from Mexican Brown Propolis on Diabetic Nephropathy
Propolis is a resinous beehive product that has been used worldwide in traditional medicine to prevent and treat colds, wounds, rheumatism, heart disease and diabetes. Diabetic nephropathy is the final stage of renal complications caused by diabetes and for its treatment there are few alternatives....
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017349/ https://www.ncbi.nlm.nih.gov/pubmed/29642511 http://dx.doi.org/10.3390/molecules23040852 |
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author | Granados-Pineda, Jessica Uribe-Uribe, Norma García-López, Patricia Ramos-Godinez, María del Pilar Rivero-Cruz, J. Fausto Pérez-Rojas, Jazmin Marlen |
author_facet | Granados-Pineda, Jessica Uribe-Uribe, Norma García-López, Patricia Ramos-Godinez, María del Pilar Rivero-Cruz, J. Fausto Pérez-Rojas, Jazmin Marlen |
author_sort | Granados-Pineda, Jessica |
collection | PubMed |
description | Propolis is a resinous beehive product that has been used worldwide in traditional medicine to prevent and treat colds, wounds, rheumatism, heart disease and diabetes. Diabetic nephropathy is the final stage of renal complications caused by diabetes and for its treatment there are few alternatives. The present study aimed to determine the chemical composition of three propolis samples collected in Chihuahua, Durango and Zacatecas and to evaluate the effect of pinocembrin in a model of diabetic nephropathy in vivo. Previous research demonstrated that propolis of Chihuahua possesses hypoglycemic and antioxidant activities. Two different schemes were assessed, preventive (before renal damage) and corrective (once renal damage is established). In the preventive scheme, pinocembrin treatment avoids death of the rats, improves lipid profile, glomerular filtration rate, urinary protein, avoid increases in urinary biomarkers, oxidative stress and glomerular basement membrane thickness. Whereas, in the corrective scheme, pinocembrin only improves lipid profile without showing improvement in any other parameters, even pinocembrin exacerbated the damage. In conclusion, pinocembrin ameliorates diabetic nephropathy when there is no kidney damage but when it is already present, pinocembrin accelerates kidney damage. |
format | Online Article Text |
id | pubmed-6017349 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-60173492018-11-13 Effect of Pinocembrin Isolated from Mexican Brown Propolis on Diabetic Nephropathy Granados-Pineda, Jessica Uribe-Uribe, Norma García-López, Patricia Ramos-Godinez, María del Pilar Rivero-Cruz, J. Fausto Pérez-Rojas, Jazmin Marlen Molecules Article Propolis is a resinous beehive product that has been used worldwide in traditional medicine to prevent and treat colds, wounds, rheumatism, heart disease and diabetes. Diabetic nephropathy is the final stage of renal complications caused by diabetes and for its treatment there are few alternatives. The present study aimed to determine the chemical composition of three propolis samples collected in Chihuahua, Durango and Zacatecas and to evaluate the effect of pinocembrin in a model of diabetic nephropathy in vivo. Previous research demonstrated that propolis of Chihuahua possesses hypoglycemic and antioxidant activities. Two different schemes were assessed, preventive (before renal damage) and corrective (once renal damage is established). In the preventive scheme, pinocembrin treatment avoids death of the rats, improves lipid profile, glomerular filtration rate, urinary protein, avoid increases in urinary biomarkers, oxidative stress and glomerular basement membrane thickness. Whereas, in the corrective scheme, pinocembrin only improves lipid profile without showing improvement in any other parameters, even pinocembrin exacerbated the damage. In conclusion, pinocembrin ameliorates diabetic nephropathy when there is no kidney damage but when it is already present, pinocembrin accelerates kidney damage. MDPI 2018-04-09 /pmc/articles/PMC6017349/ /pubmed/29642511 http://dx.doi.org/10.3390/molecules23040852 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Granados-Pineda, Jessica Uribe-Uribe, Norma García-López, Patricia Ramos-Godinez, María del Pilar Rivero-Cruz, J. Fausto Pérez-Rojas, Jazmin Marlen Effect of Pinocembrin Isolated from Mexican Brown Propolis on Diabetic Nephropathy |
title | Effect of Pinocembrin Isolated from Mexican Brown Propolis on Diabetic Nephropathy |
title_full | Effect of Pinocembrin Isolated from Mexican Brown Propolis on Diabetic Nephropathy |
title_fullStr | Effect of Pinocembrin Isolated from Mexican Brown Propolis on Diabetic Nephropathy |
title_full_unstemmed | Effect of Pinocembrin Isolated from Mexican Brown Propolis on Diabetic Nephropathy |
title_short | Effect of Pinocembrin Isolated from Mexican Brown Propolis on Diabetic Nephropathy |
title_sort | effect of pinocembrin isolated from mexican brown propolis on diabetic nephropathy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017349/ https://www.ncbi.nlm.nih.gov/pubmed/29642511 http://dx.doi.org/10.3390/molecules23040852 |
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