Small Peptides Able to Suppress Prostaglandin E(2) Generation in Renal Mesangial Cells

Peptide drug discovery may play a key role in the identification of novel medicinal agents. Here, we present the development of novel small peptides able to suppress the production of PGE(2) in mesangial cells. The new compounds were generated by structural alterations applied on GK115, a novel inhi...

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Detalles Bibliográficos
Autores principales: Vasilakaki, Sofia, Pastukhov, Oleksandr, Mavromoustakos, Thomas, Huwiler, Andrea, Kokotos, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017359/
https://www.ncbi.nlm.nih.gov/pubmed/29342835
http://dx.doi.org/10.3390/molecules23010158
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author Vasilakaki, Sofia
Pastukhov, Oleksandr
Mavromoustakos, Thomas
Huwiler, Andrea
Kokotos, George
author_facet Vasilakaki, Sofia
Pastukhov, Oleksandr
Mavromoustakos, Thomas
Huwiler, Andrea
Kokotos, George
author_sort Vasilakaki, Sofia
collection PubMed
description Peptide drug discovery may play a key role in the identification of novel medicinal agents. Here, we present the development of novel small peptides able to suppress the production of PGE(2) in mesangial cells. The new compounds were generated by structural alterations applied on GK115, a novel inhibitor of secreted phospholipase A(2), which has been previously shown to reduce PGE(2) synthesis in rat renal mesangial cells. Among the synthesized compounds, the tripeptide derivative 11 exhibited a nice dose-dependent suppression of PGE(2) production, similar to that observed for GK115.
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spelling pubmed-60173592018-11-13 Small Peptides Able to Suppress Prostaglandin E(2) Generation in Renal Mesangial Cells Vasilakaki, Sofia Pastukhov, Oleksandr Mavromoustakos, Thomas Huwiler, Andrea Kokotos, George Molecules Article Peptide drug discovery may play a key role in the identification of novel medicinal agents. Here, we present the development of novel small peptides able to suppress the production of PGE(2) in mesangial cells. The new compounds were generated by structural alterations applied on GK115, a novel inhibitor of secreted phospholipase A(2), which has been previously shown to reduce PGE(2) synthesis in rat renal mesangial cells. Among the synthesized compounds, the tripeptide derivative 11 exhibited a nice dose-dependent suppression of PGE(2) production, similar to that observed for GK115. MDPI 2018-01-13 /pmc/articles/PMC6017359/ /pubmed/29342835 http://dx.doi.org/10.3390/molecules23010158 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Vasilakaki, Sofia
Pastukhov, Oleksandr
Mavromoustakos, Thomas
Huwiler, Andrea
Kokotos, George
Small Peptides Able to Suppress Prostaglandin E(2) Generation in Renal Mesangial Cells
title Small Peptides Able to Suppress Prostaglandin E(2) Generation in Renal Mesangial Cells
title_full Small Peptides Able to Suppress Prostaglandin E(2) Generation in Renal Mesangial Cells
title_fullStr Small Peptides Able to Suppress Prostaglandin E(2) Generation in Renal Mesangial Cells
title_full_unstemmed Small Peptides Able to Suppress Prostaglandin E(2) Generation in Renal Mesangial Cells
title_short Small Peptides Able to Suppress Prostaglandin E(2) Generation in Renal Mesangial Cells
title_sort small peptides able to suppress prostaglandin e(2) generation in renal mesangial cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017359/
https://www.ncbi.nlm.nih.gov/pubmed/29342835
http://dx.doi.org/10.3390/molecules23010158
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