Three New Polyynes from Codonopsis pilosula and Their Activities on Lipid Metabolism

Three new polyynes, named choushenpilosulynes A–C (1–3), were isolated from an 85% aqueous EtOH extract of the roots of Codonopsis pilosula cultivated in Xundian County of Yunnan province, China. Their structures, including the absolute configuration of the glucose residue in 1 and 2, were determine...

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Autores principales: Hu, Xiao-Yu, Qin, Fu-Ying, Lu, Xi-Feng, Zhang, Lan-Sheng, Cheng, Yong-Xian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017398/
https://www.ncbi.nlm.nih.gov/pubmed/29649098
http://dx.doi.org/10.3390/molecules23040887
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author Hu, Xiao-Yu
Qin, Fu-Ying
Lu, Xi-Feng
Zhang, Lan-Sheng
Cheng, Yong-Xian
author_facet Hu, Xiao-Yu
Qin, Fu-Ying
Lu, Xi-Feng
Zhang, Lan-Sheng
Cheng, Yong-Xian
author_sort Hu, Xiao-Yu
collection PubMed
description Three new polyynes, named choushenpilosulynes A–C (1–3), were isolated from an 85% aqueous EtOH extract of the roots of Codonopsis pilosula cultivated in Xundian County of Yunnan province, China. Their structures, including the absolute configuration of the glucose residue in 1 and 2, were determined by spectroscopic analysis and gas chromatography (GC). In addition, biological evaluation shows that all the compounds can inhibit the expression of the squalene monooxygenase (SQLE) gene in HepG2 cells, suggesting that these compounds may be involved in lipid metabolism.
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spelling pubmed-60173982018-11-13 Three New Polyynes from Codonopsis pilosula and Their Activities on Lipid Metabolism Hu, Xiao-Yu Qin, Fu-Ying Lu, Xi-Feng Zhang, Lan-Sheng Cheng, Yong-Xian Molecules Article Three new polyynes, named choushenpilosulynes A–C (1–3), were isolated from an 85% aqueous EtOH extract of the roots of Codonopsis pilosula cultivated in Xundian County of Yunnan province, China. Their structures, including the absolute configuration of the glucose residue in 1 and 2, were determined by spectroscopic analysis and gas chromatography (GC). In addition, biological evaluation shows that all the compounds can inhibit the expression of the squalene monooxygenase (SQLE) gene in HepG2 cells, suggesting that these compounds may be involved in lipid metabolism. MDPI 2018-04-12 /pmc/articles/PMC6017398/ /pubmed/29649098 http://dx.doi.org/10.3390/molecules23040887 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hu, Xiao-Yu
Qin, Fu-Ying
Lu, Xi-Feng
Zhang, Lan-Sheng
Cheng, Yong-Xian
Three New Polyynes from Codonopsis pilosula and Their Activities on Lipid Metabolism
title Three New Polyynes from Codonopsis pilosula and Their Activities on Lipid Metabolism
title_full Three New Polyynes from Codonopsis pilosula and Their Activities on Lipid Metabolism
title_fullStr Three New Polyynes from Codonopsis pilosula and Their Activities on Lipid Metabolism
title_full_unstemmed Three New Polyynes from Codonopsis pilosula and Their Activities on Lipid Metabolism
title_short Three New Polyynes from Codonopsis pilosula and Their Activities on Lipid Metabolism
title_sort three new polyynes from codonopsis pilosula and their activities on lipid metabolism
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017398/
https://www.ncbi.nlm.nih.gov/pubmed/29649098
http://dx.doi.org/10.3390/molecules23040887
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