Cargando…
Iridoids and Other Monoterpenes in the Alzheimer’s Brain: Recent Development and Future Prospects
Iridoids are a class of monoterpenoid compounds constructed from 10-carbon skeleton of isoprene building units. These compounds in their aglycones and glycosylated forms exist in nature to contribute to mechanisms related to plant defenses and diverse plant-animal interactions. Recent studies have a...
Autor principal: | |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017424/ https://www.ncbi.nlm.nih.gov/pubmed/29316661 http://dx.doi.org/10.3390/molecules23010117 |
_version_ | 1783334746643759104 |
---|---|
author | Habtemariam, Solomon |
author_facet | Habtemariam, Solomon |
author_sort | Habtemariam, Solomon |
collection | PubMed |
description | Iridoids are a class of monoterpenoid compounds constructed from 10-carbon skeleton of isoprene building units. These compounds in their aglycones and glycosylated forms exist in nature to contribute to mechanisms related to plant defenses and diverse plant-animal interactions. Recent studies have also shown that iridoids and other structurally related monoterpenes display a vast array of pharmacological effects that make them potential modulators of the Alzheimer’s disease (AD). This review critically evaluates the therapeutic potential of these natural products by assessing key in vitro and in vivo data published in the scientific literature. Mechanistic approach of scrutiny addressing their effects in the Alzheimer’s brain including the τ-protein phosphorylation signaling, amyloid beta (Aβ) formation, aggregation, toxicity and clearance along with various effects from antioxidant to antiinflammatory mechanisms are discussed. The drug likeness of these compounds and future prospects to consider in their development as potential leads are addressed. |
format | Online Article Text |
id | pubmed-6017424 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-60174242018-11-13 Iridoids and Other Monoterpenes in the Alzheimer’s Brain: Recent Development and Future Prospects Habtemariam, Solomon Molecules Review Iridoids are a class of monoterpenoid compounds constructed from 10-carbon skeleton of isoprene building units. These compounds in their aglycones and glycosylated forms exist in nature to contribute to mechanisms related to plant defenses and diverse plant-animal interactions. Recent studies have also shown that iridoids and other structurally related monoterpenes display a vast array of pharmacological effects that make them potential modulators of the Alzheimer’s disease (AD). This review critically evaluates the therapeutic potential of these natural products by assessing key in vitro and in vivo data published in the scientific literature. Mechanistic approach of scrutiny addressing their effects in the Alzheimer’s brain including the τ-protein phosphorylation signaling, amyloid beta (Aβ) formation, aggregation, toxicity and clearance along with various effects from antioxidant to antiinflammatory mechanisms are discussed. The drug likeness of these compounds and future prospects to consider in their development as potential leads are addressed. MDPI 2018-01-07 /pmc/articles/PMC6017424/ /pubmed/29316661 http://dx.doi.org/10.3390/molecules23010117 Text en © 2018 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Habtemariam, Solomon Iridoids and Other Monoterpenes in the Alzheimer’s Brain: Recent Development and Future Prospects |
title | Iridoids and Other Monoterpenes in the Alzheimer’s Brain: Recent Development and Future Prospects |
title_full | Iridoids and Other Monoterpenes in the Alzheimer’s Brain: Recent Development and Future Prospects |
title_fullStr | Iridoids and Other Monoterpenes in the Alzheimer’s Brain: Recent Development and Future Prospects |
title_full_unstemmed | Iridoids and Other Monoterpenes in the Alzheimer’s Brain: Recent Development and Future Prospects |
title_short | Iridoids and Other Monoterpenes in the Alzheimer’s Brain: Recent Development and Future Prospects |
title_sort | iridoids and other monoterpenes in the alzheimer’s brain: recent development and future prospects |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017424/ https://www.ncbi.nlm.nih.gov/pubmed/29316661 http://dx.doi.org/10.3390/molecules23010117 |
work_keys_str_mv | AT habtemariamsolomon iridoidsandothermonoterpenesinthealzheimersbrainrecentdevelopmentandfutureprospects |