Synthesis of Polyheterocyclic Pyrrolo[3,4-b]pyridin-5-ones via a One-Pot (Ugi-3CR/aza Diels-Alder/N-acylation/aromatization/S(N)2) Process. A Suitable Alternative towards Novel Aza-Analogues of Falipamil

We describe the one-pot synthesis of twenty polyheterocyclic pyrrolo[3,4-b]pyridin-5-ones via a cascade process (Ugi-3CR/aza Diels-Alder/N-acylation/aromatization) in 20 to 95% overall yields, as well as four pharmacologically promising analogues via an improved cascade process (Ugi-3CR/aza Diels-Al...

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Detalles Bibliográficos
Autores principales: Zamudio-Medina, Angel, García-González, Ailyn N., Herrera-Carrillo, Genesis K., Zárate-Zárate, Daniel, Benavides-Macías, Adriana, Tamariz, Joaquín, Ibarra, Ilich A., Islas-Jácome, Alejandro, González-Zamora, Eduardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017480/
https://www.ncbi.nlm.nih.gov/pubmed/29584639
http://dx.doi.org/10.3390/molecules23040763

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017480/
https://www.ncbi.nlm.nih.gov/pubmed/29584639
http://dx.doi.org/10.3390/molecules23040763

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