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Resveratrol-Inspired Benzo[b]selenophenes Act as Anti-Oxidants in Yeast

Resveratrol is a natural (poly)phenol primarily found in plants protecting them against pathogens, as well as harmful effects of physical and chemical agents. In higher eukaryotic cells and organisms, this compound displays a remarkable range of biological activities, such as anti-oxidant, anti-infl...

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Autores principales: Mániková, Dominika, Šestáková, Zuzana, Rendeková, Jana, Vlasáková, Danuša, Lukáčová, Patrícia, Paegle, Edgars, Arsenyan, Pavel, Chovanec, Miroslav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017489/
https://www.ncbi.nlm.nih.gov/pubmed/29495287
http://dx.doi.org/10.3390/molecules23020507
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author Mániková, Dominika
Šestáková, Zuzana
Rendeková, Jana
Vlasáková, Danuša
Lukáčová, Patrícia
Paegle, Edgars
Arsenyan, Pavel
Chovanec, Miroslav
author_facet Mániková, Dominika
Šestáková, Zuzana
Rendeková, Jana
Vlasáková, Danuša
Lukáčová, Patrícia
Paegle, Edgars
Arsenyan, Pavel
Chovanec, Miroslav
author_sort Mániková, Dominika
collection PubMed
description Resveratrol is a natural (poly)phenol primarily found in plants protecting them against pathogens, as well as harmful effects of physical and chemical agents. In higher eukaryotic cells and organisms, this compound displays a remarkable range of biological activities, such as anti-oxidant, anti-inflammatory, anti-cancer, anti-aging, cardio- and neuro-protective properties. Here, biological activities of synthetic selenium-containing derivatives of resveratrol—benzo[b]selenophenes—have been studied in lower eukaryotes Saccharomyces cerevisiae. Their toxicity, as well as DNA damaging and reactive oxygen species (ROS) inducing potencies, manifested through their ability to act as redox active anti-microbial agents, have been examined. We show that some benzo[b]selenophenes can kill yeast cells and that the killing effects are not mediated by DNA damage types that can be detected as DNA double-strand breaks. These benzo[b]selenophenes could potentially be used as anti-fungal agents, although their concentrations relevant to application in humans need to be further evaluated. In addition, most of the studied benzo[b]selenophenes display redox-modulating/anti-oxidant activity (comparable or even higher than that of resveratrol or Trolox) causing a decrease in the intracellular ROS levels in yeast cells. Therefore, after careful re-evaluation in other biological systems these observations might be transferred to humans, where resveratrol-inspired benzo[b]selenophenes could be used as supra-anti-oxidant supplements.
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spelling pubmed-60174892018-11-13 Resveratrol-Inspired Benzo[b]selenophenes Act as Anti-Oxidants in Yeast Mániková, Dominika Šestáková, Zuzana Rendeková, Jana Vlasáková, Danuša Lukáčová, Patrícia Paegle, Edgars Arsenyan, Pavel Chovanec, Miroslav Molecules Article Resveratrol is a natural (poly)phenol primarily found in plants protecting them against pathogens, as well as harmful effects of physical and chemical agents. In higher eukaryotic cells and organisms, this compound displays a remarkable range of biological activities, such as anti-oxidant, anti-inflammatory, anti-cancer, anti-aging, cardio- and neuro-protective properties. Here, biological activities of synthetic selenium-containing derivatives of resveratrol—benzo[b]selenophenes—have been studied in lower eukaryotes Saccharomyces cerevisiae. Their toxicity, as well as DNA damaging and reactive oxygen species (ROS) inducing potencies, manifested through their ability to act as redox active anti-microbial agents, have been examined. We show that some benzo[b]selenophenes can kill yeast cells and that the killing effects are not mediated by DNA damage types that can be detected as DNA double-strand breaks. These benzo[b]selenophenes could potentially be used as anti-fungal agents, although their concentrations relevant to application in humans need to be further evaluated. In addition, most of the studied benzo[b]selenophenes display redox-modulating/anti-oxidant activity (comparable or even higher than that of resveratrol or Trolox) causing a decrease in the intracellular ROS levels in yeast cells. Therefore, after careful re-evaluation in other biological systems these observations might be transferred to humans, where resveratrol-inspired benzo[b]selenophenes could be used as supra-anti-oxidant supplements. MDPI 2018-02-24 /pmc/articles/PMC6017489/ /pubmed/29495287 http://dx.doi.org/10.3390/molecules23020507 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mániková, Dominika
Šestáková, Zuzana
Rendeková, Jana
Vlasáková, Danuša
Lukáčová, Patrícia
Paegle, Edgars
Arsenyan, Pavel
Chovanec, Miroslav
Resveratrol-Inspired Benzo[b]selenophenes Act as Anti-Oxidants in Yeast
title Resveratrol-Inspired Benzo[b]selenophenes Act as Anti-Oxidants in Yeast
title_full Resveratrol-Inspired Benzo[b]selenophenes Act as Anti-Oxidants in Yeast
title_fullStr Resveratrol-Inspired Benzo[b]selenophenes Act as Anti-Oxidants in Yeast
title_full_unstemmed Resveratrol-Inspired Benzo[b]selenophenes Act as Anti-Oxidants in Yeast
title_short Resveratrol-Inspired Benzo[b]selenophenes Act as Anti-Oxidants in Yeast
title_sort resveratrol-inspired benzo[b]selenophenes act as anti-oxidants in yeast
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017489/
https://www.ncbi.nlm.nih.gov/pubmed/29495287
http://dx.doi.org/10.3390/molecules23020507
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