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Curcumin Analog CH-5 Suppresses the Proliferation, Migration, and Invasion of the Human Gastric Cancer Cell Line HGC-27
Gastric cancer is one of the most frequent malignant tumors in the world. The majority of patients are diagnosed with metastatic gastric cancer, which has a low survival rate. These data reinforce the importance of studying the anticancer activity of new molecules with the potential to suppress gast...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017500/ https://www.ncbi.nlm.nih.gov/pubmed/29385675 http://dx.doi.org/10.3390/molecules23020279 |
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author | Silva, Gabriel Teixeira Lima, Felipe Seba, Viviane Mendes Lourenço, Ana Laura Lucas, Thaise Graminha de Andrade, Bianca Vieira Torrezan, Guilherme Silva Polaquini, Carlos Roberto Garcia, Marcelo Engracia Couto, Lucélio Bernardes Bestetti, Reinaldo Bulgarelli de Castro França, Suzelei Fachin, Ana Lúcia Regasini, Luis Octavio Marins, Mozart |
author_facet | Silva, Gabriel Teixeira Lima, Felipe Seba, Viviane Mendes Lourenço, Ana Laura Lucas, Thaise Graminha de Andrade, Bianca Vieira Torrezan, Guilherme Silva Polaquini, Carlos Roberto Garcia, Marcelo Engracia Couto, Lucélio Bernardes Bestetti, Reinaldo Bulgarelli de Castro França, Suzelei Fachin, Ana Lúcia Regasini, Luis Octavio Marins, Mozart |
author_sort | Silva, Gabriel |
collection | PubMed |
description | Gastric cancer is one of the most frequent malignant tumors in the world. The majority of patients are diagnosed with metastatic gastric cancer, which has a low survival rate. These data reinforce the importance of studying the anticancer activity of new molecules with the potential to suppress gastric cancer metastasis. Curcumin is a well-studied compound that has demonstrated anti-metastatic effects. Here we investigated if CH-5, a curcumin derivative compound, has anti-metastatic properties in the human gastric cancer cell line HGC-27. Firstly, we found that CH-5 decreased viability and induced apoptosis in HGC-27 cells in a dose-dependent manner. Additionally, CH-5 suppressed the migration and invasion of HGC-27 cells by downregulating the expression and collagenase activity of matrix metalloproteinase 2 in a dose-dependent manner. In conclusion, CH-5 showed anticancer activities, including the induction of apoptosis, and the suppression of migration and invasion in HGC-27 cells, suggesting that CH-5 can be a lead molecule for the development of anti-metastatic drugs for gastric cancer therapy. |
format | Online Article Text |
id | pubmed-6017500 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-60175002018-11-13 Curcumin Analog CH-5 Suppresses the Proliferation, Migration, and Invasion of the Human Gastric Cancer Cell Line HGC-27 Silva, Gabriel Teixeira Lima, Felipe Seba, Viviane Mendes Lourenço, Ana Laura Lucas, Thaise Graminha de Andrade, Bianca Vieira Torrezan, Guilherme Silva Polaquini, Carlos Roberto Garcia, Marcelo Engracia Couto, Lucélio Bernardes Bestetti, Reinaldo Bulgarelli de Castro França, Suzelei Fachin, Ana Lúcia Regasini, Luis Octavio Marins, Mozart Molecules Communication Gastric cancer is one of the most frequent malignant tumors in the world. The majority of patients are diagnosed with metastatic gastric cancer, which has a low survival rate. These data reinforce the importance of studying the anticancer activity of new molecules with the potential to suppress gastric cancer metastasis. Curcumin is a well-studied compound that has demonstrated anti-metastatic effects. Here we investigated if CH-5, a curcumin derivative compound, has anti-metastatic properties in the human gastric cancer cell line HGC-27. Firstly, we found that CH-5 decreased viability and induced apoptosis in HGC-27 cells in a dose-dependent manner. Additionally, CH-5 suppressed the migration and invasion of HGC-27 cells by downregulating the expression and collagenase activity of matrix metalloproteinase 2 in a dose-dependent manner. In conclusion, CH-5 showed anticancer activities, including the induction of apoptosis, and the suppression of migration and invasion in HGC-27 cells, suggesting that CH-5 can be a lead molecule for the development of anti-metastatic drugs for gastric cancer therapy. MDPI 2018-01-30 /pmc/articles/PMC6017500/ /pubmed/29385675 http://dx.doi.org/10.3390/molecules23020279 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Silva, Gabriel Teixeira Lima, Felipe Seba, Viviane Mendes Lourenço, Ana Laura Lucas, Thaise Graminha de Andrade, Bianca Vieira Torrezan, Guilherme Silva Polaquini, Carlos Roberto Garcia, Marcelo Engracia Couto, Lucélio Bernardes Bestetti, Reinaldo Bulgarelli de Castro França, Suzelei Fachin, Ana Lúcia Regasini, Luis Octavio Marins, Mozart Curcumin Analog CH-5 Suppresses the Proliferation, Migration, and Invasion of the Human Gastric Cancer Cell Line HGC-27 |
title | Curcumin Analog CH-5 Suppresses the Proliferation, Migration, and Invasion of the Human Gastric Cancer Cell Line HGC-27 |
title_full | Curcumin Analog CH-5 Suppresses the Proliferation, Migration, and Invasion of the Human Gastric Cancer Cell Line HGC-27 |
title_fullStr | Curcumin Analog CH-5 Suppresses the Proliferation, Migration, and Invasion of the Human Gastric Cancer Cell Line HGC-27 |
title_full_unstemmed | Curcumin Analog CH-5 Suppresses the Proliferation, Migration, and Invasion of the Human Gastric Cancer Cell Line HGC-27 |
title_short | Curcumin Analog CH-5 Suppresses the Proliferation, Migration, and Invasion of the Human Gastric Cancer Cell Line HGC-27 |
title_sort | curcumin analog ch-5 suppresses the proliferation, migration, and invasion of the human gastric cancer cell line hgc-27 |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017500/ https://www.ncbi.nlm.nih.gov/pubmed/29385675 http://dx.doi.org/10.3390/molecules23020279 |
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