Steroidal Constituents from Roots and Rhizomes of Smilacina japonica

Four new steroidal constituents (1–4) along with two known steroidal glycosides (5 and 6) were isolated from the roots and rhizomes of Smilacina japonica. Analysis of their physicochemical properties and spectroscopic profiles identified the compounds as (25S)-5α-spirostan-9(11)-en-3β, 17α-diol (1);...

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Autores principales: Cui, Yuwen, Yang, Xinjie, Zhang, Dongdong, Li, Yuze, Zhang, Li, Song, Bei, Yue, Zhenggang, Song, Xiaomei, Tang, Haifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017528/
https://www.ncbi.nlm.nih.gov/pubmed/29601498
http://dx.doi.org/10.3390/molecules23040798
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author Cui, Yuwen
Yang, Xinjie
Zhang, Dongdong
Li, Yuze
Zhang, Li
Song, Bei
Yue, Zhenggang
Song, Xiaomei
Tang, Haifeng
author_facet Cui, Yuwen
Yang, Xinjie
Zhang, Dongdong
Li, Yuze
Zhang, Li
Song, Bei
Yue, Zhenggang
Song, Xiaomei
Tang, Haifeng
author_sort Cui, Yuwen
collection PubMed
description Four new steroidal constituents (1–4) along with two known steroidal glycosides (5 and 6) were isolated from the roots and rhizomes of Smilacina japonica. Analysis of their physicochemical properties and spectroscopic profiles identified the compounds as (25S)-5α-spirostan-9(11)-en-3β, 17α-diol (1); (25S)-5α-spirostan-9(11)-en-3β, 12β-diol (2); (25S)-5α-spirostan-9(11)-en-3β, 17α-diol-3-O-β-d-glucopyranoside (3); (25S)-5α-spirostan-9(11)-en-3β, 17α-diol-3-O-β-d-glucopyranosyl-(1→2)-[β-d-glucopyranosyl-(1→3)]-β-d-galactopyranoside (4); japonicoside B (5); and japonicoside C (6). All six compounds showed cytotoxic activity against SMMC-7712, Bel-7402, A549, H460, and K562 human cancer cells.
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spelling pubmed-60175282018-11-13 Steroidal Constituents from Roots and Rhizomes of Smilacina japonica Cui, Yuwen Yang, Xinjie Zhang, Dongdong Li, Yuze Zhang, Li Song, Bei Yue, Zhenggang Song, Xiaomei Tang, Haifeng Molecules Article Four new steroidal constituents (1–4) along with two known steroidal glycosides (5 and 6) were isolated from the roots and rhizomes of Smilacina japonica. Analysis of their physicochemical properties and spectroscopic profiles identified the compounds as (25S)-5α-spirostan-9(11)-en-3β, 17α-diol (1); (25S)-5α-spirostan-9(11)-en-3β, 12β-diol (2); (25S)-5α-spirostan-9(11)-en-3β, 17α-diol-3-O-β-d-glucopyranoside (3); (25S)-5α-spirostan-9(11)-en-3β, 17α-diol-3-O-β-d-glucopyranosyl-(1→2)-[β-d-glucopyranosyl-(1→3)]-β-d-galactopyranoside (4); japonicoside B (5); and japonicoside C (6). All six compounds showed cytotoxic activity against SMMC-7712, Bel-7402, A549, H460, and K562 human cancer cells. MDPI 2018-03-30 /pmc/articles/PMC6017528/ /pubmed/29601498 http://dx.doi.org/10.3390/molecules23040798 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cui, Yuwen
Yang, Xinjie
Zhang, Dongdong
Li, Yuze
Zhang, Li
Song, Bei
Yue, Zhenggang
Song, Xiaomei
Tang, Haifeng
Steroidal Constituents from Roots and Rhizomes of Smilacina japonica
title Steroidal Constituents from Roots and Rhizomes of Smilacina japonica
title_full Steroidal Constituents from Roots and Rhizomes of Smilacina japonica
title_fullStr Steroidal Constituents from Roots and Rhizomes of Smilacina japonica
title_full_unstemmed Steroidal Constituents from Roots and Rhizomes of Smilacina japonica
title_short Steroidal Constituents from Roots and Rhizomes of Smilacina japonica
title_sort steroidal constituents from roots and rhizomes of smilacina japonica
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017528/
https://www.ncbi.nlm.nih.gov/pubmed/29601498
http://dx.doi.org/10.3390/molecules23040798
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