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Aethiopinolones A–E, New Pregnenolone Type Steroids from the East African Basidiomycete Fomitiporia aethiopica
A mycelial culture of the Kenyan basidiomycete Fomitiporia aethiopica was fermented on rice and the cultures were extracted with methanol. Subsequent HPLC profiling and preparative chromatography of its crude extract led to the isolation of five previously undescribed pregnenolone type triterpenes 1...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017562/ https://www.ncbi.nlm.nih.gov/pubmed/29425150 http://dx.doi.org/10.3390/molecules23020369 |
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author | Chepkirui, Clara Sum, Winnie C. Cheng, Tian Matasyoh, Josphat C. Decock, Cony Stadler, Marc |
author_facet | Chepkirui, Clara Sum, Winnie C. Cheng, Tian Matasyoh, Josphat C. Decock, Cony Stadler, Marc |
author_sort | Chepkirui, Clara |
collection | PubMed |
description | A mycelial culture of the Kenyan basidiomycete Fomitiporia aethiopica was fermented on rice and the cultures were extracted with methanol. Subsequent HPLC profiling and preparative chromatography of its crude extract led to the isolation of five previously undescribed pregnenolone type triterpenes 1–5, for which we propose the trivial name aethiopinolones A–E. The chemical structures of the aethiopinolones were determined by extensive 1D- and 2D-NMR, and HRMS data analysis. The compounds exhibited moderate cytotoxic effects against various human cancer cell lines, but they were found devoid of significant nematicidal and antimicrobial activities. |
format | Online Article Text |
id | pubmed-6017562 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-60175622018-11-13 Aethiopinolones A–E, New Pregnenolone Type Steroids from the East African Basidiomycete Fomitiporia aethiopica Chepkirui, Clara Sum, Winnie C. Cheng, Tian Matasyoh, Josphat C. Decock, Cony Stadler, Marc Molecules Article A mycelial culture of the Kenyan basidiomycete Fomitiporia aethiopica was fermented on rice and the cultures were extracted with methanol. Subsequent HPLC profiling and preparative chromatography of its crude extract led to the isolation of five previously undescribed pregnenolone type triterpenes 1–5, for which we propose the trivial name aethiopinolones A–E. The chemical structures of the aethiopinolones were determined by extensive 1D- and 2D-NMR, and HRMS data analysis. The compounds exhibited moderate cytotoxic effects against various human cancer cell lines, but they were found devoid of significant nematicidal and antimicrobial activities. MDPI 2018-02-09 /pmc/articles/PMC6017562/ /pubmed/29425150 http://dx.doi.org/10.3390/molecules23020369 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Chepkirui, Clara Sum, Winnie C. Cheng, Tian Matasyoh, Josphat C. Decock, Cony Stadler, Marc Aethiopinolones A–E, New Pregnenolone Type Steroids from the East African Basidiomycete Fomitiporia aethiopica |
title | Aethiopinolones A–E, New Pregnenolone Type Steroids from the East African Basidiomycete Fomitiporia aethiopica |
title_full | Aethiopinolones A–E, New Pregnenolone Type Steroids from the East African Basidiomycete Fomitiporia aethiopica |
title_fullStr | Aethiopinolones A–E, New Pregnenolone Type Steroids from the East African Basidiomycete Fomitiporia aethiopica |
title_full_unstemmed | Aethiopinolones A–E, New Pregnenolone Type Steroids from the East African Basidiomycete Fomitiporia aethiopica |
title_short | Aethiopinolones A–E, New Pregnenolone Type Steroids from the East African Basidiomycete Fomitiporia aethiopica |
title_sort | aethiopinolones a–e, new pregnenolone type steroids from the east african basidiomycete fomitiporia aethiopica |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017562/ https://www.ncbi.nlm.nih.gov/pubmed/29425150 http://dx.doi.org/10.3390/molecules23020369 |
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