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Aethiopinolones A–E, New Pregnenolone Type Steroids from the East African Basidiomycete Fomitiporia aethiopica

A mycelial culture of the Kenyan basidiomycete Fomitiporia aethiopica was fermented on rice and the cultures were extracted with methanol. Subsequent HPLC profiling and preparative chromatography of its crude extract led to the isolation of five previously undescribed pregnenolone type triterpenes 1...

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Autores principales: Chepkirui, Clara, Sum, Winnie C., Cheng, Tian, Matasyoh, Josphat C., Decock, Cony, Stadler, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017562/
https://www.ncbi.nlm.nih.gov/pubmed/29425150
http://dx.doi.org/10.3390/molecules23020369
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author Chepkirui, Clara
Sum, Winnie C.
Cheng, Tian
Matasyoh, Josphat C.
Decock, Cony
Stadler, Marc
author_facet Chepkirui, Clara
Sum, Winnie C.
Cheng, Tian
Matasyoh, Josphat C.
Decock, Cony
Stadler, Marc
author_sort Chepkirui, Clara
collection PubMed
description A mycelial culture of the Kenyan basidiomycete Fomitiporia aethiopica was fermented on rice and the cultures were extracted with methanol. Subsequent HPLC profiling and preparative chromatography of its crude extract led to the isolation of five previously undescribed pregnenolone type triterpenes 1–5, for which we propose the trivial name aethiopinolones A–E. The chemical structures of the aethiopinolones were determined by extensive 1D- and 2D-NMR, and HRMS data analysis. The compounds exhibited moderate cytotoxic effects against various human cancer cell lines, but they were found devoid of significant nematicidal and antimicrobial activities.
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spelling pubmed-60175622018-11-13 Aethiopinolones A–E, New Pregnenolone Type Steroids from the East African Basidiomycete Fomitiporia aethiopica Chepkirui, Clara Sum, Winnie C. Cheng, Tian Matasyoh, Josphat C. Decock, Cony Stadler, Marc Molecules Article A mycelial culture of the Kenyan basidiomycete Fomitiporia aethiopica was fermented on rice and the cultures were extracted with methanol. Subsequent HPLC profiling and preparative chromatography of its crude extract led to the isolation of five previously undescribed pregnenolone type triterpenes 1–5, for which we propose the trivial name aethiopinolones A–E. The chemical structures of the aethiopinolones were determined by extensive 1D- and 2D-NMR, and HRMS data analysis. The compounds exhibited moderate cytotoxic effects against various human cancer cell lines, but they were found devoid of significant nematicidal and antimicrobial activities. MDPI 2018-02-09 /pmc/articles/PMC6017562/ /pubmed/29425150 http://dx.doi.org/10.3390/molecules23020369 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chepkirui, Clara
Sum, Winnie C.
Cheng, Tian
Matasyoh, Josphat C.
Decock, Cony
Stadler, Marc
Aethiopinolones A–E, New Pregnenolone Type Steroids from the East African Basidiomycete Fomitiporia aethiopica
title Aethiopinolones A–E, New Pregnenolone Type Steroids from the East African Basidiomycete Fomitiporia aethiopica
title_full Aethiopinolones A–E, New Pregnenolone Type Steroids from the East African Basidiomycete Fomitiporia aethiopica
title_fullStr Aethiopinolones A–E, New Pregnenolone Type Steroids from the East African Basidiomycete Fomitiporia aethiopica
title_full_unstemmed Aethiopinolones A–E, New Pregnenolone Type Steroids from the East African Basidiomycete Fomitiporia aethiopica
title_short Aethiopinolones A–E, New Pregnenolone Type Steroids from the East African Basidiomycete Fomitiporia aethiopica
title_sort aethiopinolones a–e, new pregnenolone type steroids from the east african basidiomycete fomitiporia aethiopica
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017562/
https://www.ncbi.nlm.nih.gov/pubmed/29425150
http://dx.doi.org/10.3390/molecules23020369
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