Bioactive Phenolic and Isocoumarin Glycosides from the Stems of Homalium paniculiflorum

Two new phenolic glycosides (1 and 2) and two new isocoumarin glycosides (3 and 4), along with 14 known compounds (5–18), were isolated from the stems of Homalium paniculiflorum. Their structures were established on the basis of extensive spectroscopic analyses and chemical methods. All new compound...

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Autores principales: Wu, Shou-Yuan, Fu, Yan-Hui, Zhou, Qi, Bai, Meng, Chen, Guang-Ying, Zhao, Si-Yu, Han, Chang-Ri, Song, Xiao-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017599/
https://www.ncbi.nlm.nih.gov/pubmed/29470386
http://dx.doi.org/10.3390/molecules23020472
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author Wu, Shou-Yuan
Fu, Yan-Hui
Zhou, Qi
Bai, Meng
Chen, Guang-Ying
Zhao, Si-Yu
Han, Chang-Ri
Song, Xiao-Ping
author_facet Wu, Shou-Yuan
Fu, Yan-Hui
Zhou, Qi
Bai, Meng
Chen, Guang-Ying
Zhao, Si-Yu
Han, Chang-Ri
Song, Xiao-Ping
author_sort Wu, Shou-Yuan
collection PubMed
description Two new phenolic glycosides (1 and 2) and two new isocoumarin glycosides (3 and 4), along with 14 known compounds (5–18), were isolated from the stems of Homalium paniculiflorum. Their structures were established on the basis of extensive spectroscopic analyses and chemical methods. All new compounds were evaluated for their anti-inflammatory activities via examining the inhibitory activity on nitric oxide (NO) production induced by lipopolysaccharide (LPS) in mouse macrophage RAW 264.7 cells in vitro. Compounds 1 and 4 exhibited inhibitory activities with IC(50) values of 30.23 ± 1.23 μM and 19.36 ± 0.19 μM, respectively.
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spelling pubmed-60175992018-11-13 Bioactive Phenolic and Isocoumarin Glycosides from the Stems of Homalium paniculiflorum Wu, Shou-Yuan Fu, Yan-Hui Zhou, Qi Bai, Meng Chen, Guang-Ying Zhao, Si-Yu Han, Chang-Ri Song, Xiao-Ping Molecules Article Two new phenolic glycosides (1 and 2) and two new isocoumarin glycosides (3 and 4), along with 14 known compounds (5–18), were isolated from the stems of Homalium paniculiflorum. Their structures were established on the basis of extensive spectroscopic analyses and chemical methods. All new compounds were evaluated for their anti-inflammatory activities via examining the inhibitory activity on nitric oxide (NO) production induced by lipopolysaccharide (LPS) in mouse macrophage RAW 264.7 cells in vitro. Compounds 1 and 4 exhibited inhibitory activities with IC(50) values of 30.23 ± 1.23 μM and 19.36 ± 0.19 μM, respectively. MDPI 2018-02-22 /pmc/articles/PMC6017599/ /pubmed/29470386 http://dx.doi.org/10.3390/molecules23020472 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wu, Shou-Yuan
Fu, Yan-Hui
Zhou, Qi
Bai, Meng
Chen, Guang-Ying
Zhao, Si-Yu
Han, Chang-Ri
Song, Xiao-Ping
Bioactive Phenolic and Isocoumarin Glycosides from the Stems of Homalium paniculiflorum
title Bioactive Phenolic and Isocoumarin Glycosides from the Stems of Homalium paniculiflorum
title_full Bioactive Phenolic and Isocoumarin Glycosides from the Stems of Homalium paniculiflorum
title_fullStr Bioactive Phenolic and Isocoumarin Glycosides from the Stems of Homalium paniculiflorum
title_full_unstemmed Bioactive Phenolic and Isocoumarin Glycosides from the Stems of Homalium paniculiflorum
title_short Bioactive Phenolic and Isocoumarin Glycosides from the Stems of Homalium paniculiflorum
title_sort bioactive phenolic and isocoumarin glycosides from the stems of homalium paniculiflorum
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017599/
https://www.ncbi.nlm.nih.gov/pubmed/29470386
http://dx.doi.org/10.3390/molecules23020472
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