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Interplay between P-Glycoprotein Expression and Resistance to Endoplasmic Reticulum Stressors
Multidrug resistance (MDR) is a phenotype of cancer cells with reduced sensitivity to a wide range of unrelated drugs. P-glycoprotein (P-gp)—a drug efflux pump (ABCB1 member of the ABC transporter gene family)—is frequently observed to be a molecular cause of MDR. The drug-efflux activity of P-gp is...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017601/ https://www.ncbi.nlm.nih.gov/pubmed/29415493 http://dx.doi.org/10.3390/molecules23020337 |
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author | Hano, Milan Tomášová, Lenka Šereš, Mário Pavlíková, Lucia Breier, Albert Sulová, Zdena |
author_facet | Hano, Milan Tomášová, Lenka Šereš, Mário Pavlíková, Lucia Breier, Albert Sulová, Zdena |
author_sort | Hano, Milan |
collection | PubMed |
description | Multidrug resistance (MDR) is a phenotype of cancer cells with reduced sensitivity to a wide range of unrelated drugs. P-glycoprotein (P-gp)—a drug efflux pump (ABCB1 member of the ABC transporter gene family)—is frequently observed to be a molecular cause of MDR. The drug-efflux activity of P-gp is considered as the underlying mechanism of drug resistance against P-gp substrates and results in failure of cancer chemotherapy. Several pathological impulses such as shortages of oxygen and glucose supply, alterations of calcium storage mechanisms and/or processes of protein N-glycosylation in the endoplasmic reticulum (ER) leads to ER stress (ERS), characterized by elevation of unfolded protein cell content and activation of the unfolded protein response (UPR). UPR is responsible for modification of protein folding pathways, removal of misfolded proteins by ER associated protein degradation (ERAD) and inhibition of proteosynthesis. However, sustained ERS may result in UPR-mediated cell death. Neoplastic cells could escape from the death pathway induced by ERS by switching UPR into pro survival mechanisms instead of apoptosis. Here, we aimed to present state of the art information about consequences of P-gp expression on mechanisms associated with ERS development and regulation of the ERAD system, particularly focused on advances in ERS-associated therapy of drug resistant malignancies. |
format | Online Article Text |
id | pubmed-6017601 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-60176012018-11-13 Interplay between P-Glycoprotein Expression and Resistance to Endoplasmic Reticulum Stressors Hano, Milan Tomášová, Lenka Šereš, Mário Pavlíková, Lucia Breier, Albert Sulová, Zdena Molecules Review Multidrug resistance (MDR) is a phenotype of cancer cells with reduced sensitivity to a wide range of unrelated drugs. P-glycoprotein (P-gp)—a drug efflux pump (ABCB1 member of the ABC transporter gene family)—is frequently observed to be a molecular cause of MDR. The drug-efflux activity of P-gp is considered as the underlying mechanism of drug resistance against P-gp substrates and results in failure of cancer chemotherapy. Several pathological impulses such as shortages of oxygen and glucose supply, alterations of calcium storage mechanisms and/or processes of protein N-glycosylation in the endoplasmic reticulum (ER) leads to ER stress (ERS), characterized by elevation of unfolded protein cell content and activation of the unfolded protein response (UPR). UPR is responsible for modification of protein folding pathways, removal of misfolded proteins by ER associated protein degradation (ERAD) and inhibition of proteosynthesis. However, sustained ERS may result in UPR-mediated cell death. Neoplastic cells could escape from the death pathway induced by ERS by switching UPR into pro survival mechanisms instead of apoptosis. Here, we aimed to present state of the art information about consequences of P-gp expression on mechanisms associated with ERS development and regulation of the ERAD system, particularly focused on advances in ERS-associated therapy of drug resistant malignancies. MDPI 2018-02-06 /pmc/articles/PMC6017601/ /pubmed/29415493 http://dx.doi.org/10.3390/molecules23020337 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Hano, Milan Tomášová, Lenka Šereš, Mário Pavlíková, Lucia Breier, Albert Sulová, Zdena Interplay between P-Glycoprotein Expression and Resistance to Endoplasmic Reticulum Stressors |
title | Interplay between P-Glycoprotein Expression and Resistance to Endoplasmic Reticulum Stressors |
title_full | Interplay between P-Glycoprotein Expression and Resistance to Endoplasmic Reticulum Stressors |
title_fullStr | Interplay between P-Glycoprotein Expression and Resistance to Endoplasmic Reticulum Stressors |
title_full_unstemmed | Interplay between P-Glycoprotein Expression and Resistance to Endoplasmic Reticulum Stressors |
title_short | Interplay between P-Glycoprotein Expression and Resistance to Endoplasmic Reticulum Stressors |
title_sort | interplay between p-glycoprotein expression and resistance to endoplasmic reticulum stressors |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017601/ https://www.ncbi.nlm.nih.gov/pubmed/29415493 http://dx.doi.org/10.3390/molecules23020337 |
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