One-Pot Synthesis of 3-Functionalized 4-Hydroxycoumarin under Catalyst-Free Conditions

A concise and efficient one-pot synthesis of 3-functionalized 4-hydroxycoumarin derivatives via a three-component domino reaction of 4-hydroxycoumarin, phenylglyoxal and 3-arylaminocyclopent-2-enone or 4-arylaminofuran-2(5H)-one under catalyst-free and microwave irradiation conditions is described....

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Detalles Bibliográficos
Autores principales: Gao, Yang, Zhang, Guo-Ning, Wang, Juxian, Bai, Xiaoguang, Li, Yiliang, Wang, Yucheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017609/
https://www.ncbi.nlm.nih.gov/pubmed/29361771
http://dx.doi.org/10.3390/molecules23010235
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author Gao, Yang
Zhang, Guo-Ning
Wang, Juxian
Bai, Xiaoguang
Li, Yiliang
Wang, Yucheng
author_facet Gao, Yang
Zhang, Guo-Ning
Wang, Juxian
Bai, Xiaoguang
Li, Yiliang
Wang, Yucheng
author_sort Gao, Yang
collection PubMed
description A concise and efficient one-pot synthesis of 3-functionalized 4-hydroxycoumarin derivatives via a three-component domino reaction of 4-hydroxycoumarin, phenylglyoxal and 3-arylaminocyclopent-2-enone or 4-arylaminofuran-2(5H)-one under catalyst-free and microwave irradiation conditions is described. This synthesis involves a group-assisted purification process, which avoids traditional recrystallization and chromatographic purification methods.
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spelling pubmed-60176092018-11-13 One-Pot Synthesis of 3-Functionalized 4-Hydroxycoumarin under Catalyst-Free Conditions Gao, Yang Zhang, Guo-Ning Wang, Juxian Bai, Xiaoguang Li, Yiliang Wang, Yucheng Molecules Article A concise and efficient one-pot synthesis of 3-functionalized 4-hydroxycoumarin derivatives via a three-component domino reaction of 4-hydroxycoumarin, phenylglyoxal and 3-arylaminocyclopent-2-enone or 4-arylaminofuran-2(5H)-one under catalyst-free and microwave irradiation conditions is described. This synthesis involves a group-assisted purification process, which avoids traditional recrystallization and chromatographic purification methods. MDPI 2018-01-22 /pmc/articles/PMC6017609/ /pubmed/29361771 http://dx.doi.org/10.3390/molecules23010235 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gao, Yang
Zhang, Guo-Ning
Wang, Juxian
Bai, Xiaoguang
Li, Yiliang
Wang, Yucheng
One-Pot Synthesis of 3-Functionalized 4-Hydroxycoumarin under Catalyst-Free Conditions
title One-Pot Synthesis of 3-Functionalized 4-Hydroxycoumarin under Catalyst-Free Conditions
title_full One-Pot Synthesis of 3-Functionalized 4-Hydroxycoumarin under Catalyst-Free Conditions
title_fullStr One-Pot Synthesis of 3-Functionalized 4-Hydroxycoumarin under Catalyst-Free Conditions
title_full_unstemmed One-Pot Synthesis of 3-Functionalized 4-Hydroxycoumarin under Catalyst-Free Conditions
title_short One-Pot Synthesis of 3-Functionalized 4-Hydroxycoumarin under Catalyst-Free Conditions
title_sort one-pot synthesis of 3-functionalized 4-hydroxycoumarin under catalyst-free conditions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017609/
https://www.ncbi.nlm.nih.gov/pubmed/29361771
http://dx.doi.org/10.3390/molecules23010235
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