Talarodiolide, a New 12-Membered Macrodiolide, and GC/MS Investigation of Culture Filtrate and Mycelial Extracts of Talaromyces pinophilus

Talarodiolide, a new 12-membered macrodiolide, was isolated and characterized from the culture filtrate of strain LT6 of Talaromyces pinophilus. The structure of (Z)-4,10-dimethyl-1,7-dioxa-cyclododeca-3,9-diene-2,8-dione was assigned essentially based on NMR and MS data. Furthermore, several known...

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Autores principales: Salvatore, Maria Michela, DellaGreca, Marina, Nicoletti, Rosario, Salvatore, Francesco, Vinale, Francesco, Naviglio, Daniele, Andolfi, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017668/
https://www.ncbi.nlm.nih.gov/pubmed/29671776
http://dx.doi.org/10.3390/molecules23040950
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author Salvatore, Maria Michela
DellaGreca, Marina
Nicoletti, Rosario
Salvatore, Francesco
Vinale, Francesco
Naviglio, Daniele
Andolfi, Anna
author_facet Salvatore, Maria Michela
DellaGreca, Marina
Nicoletti, Rosario
Salvatore, Francesco
Vinale, Francesco
Naviglio, Daniele
Andolfi, Anna
author_sort Salvatore, Maria Michela
collection PubMed
description Talarodiolide, a new 12-membered macrodiolide, was isolated and characterized from the culture filtrate of strain LT6 of Talaromyces pinophilus. The structure of (Z)-4,10-dimethyl-1,7-dioxa-cyclododeca-3,9-diene-2,8-dione was assigned essentially based on NMR and MS data. Furthermore, several known compounds were isolated and identified in the crude extract of the culture filtrate and mycelium of this strain. EI mass spectrum at 70 eV of all isolated metabolites was acquired and compiled in a custom GC/MS library to be employed to detect metabolites in the crude extracts.
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spelling pubmed-60176682018-11-13 Talarodiolide, a New 12-Membered Macrodiolide, and GC/MS Investigation of Culture Filtrate and Mycelial Extracts of Talaromyces pinophilus Salvatore, Maria Michela DellaGreca, Marina Nicoletti, Rosario Salvatore, Francesco Vinale, Francesco Naviglio, Daniele Andolfi, Anna Molecules Article Talarodiolide, a new 12-membered macrodiolide, was isolated and characterized from the culture filtrate of strain LT6 of Talaromyces pinophilus. The structure of (Z)-4,10-dimethyl-1,7-dioxa-cyclododeca-3,9-diene-2,8-dione was assigned essentially based on NMR and MS data. Furthermore, several known compounds were isolated and identified in the crude extract of the culture filtrate and mycelium of this strain. EI mass spectrum at 70 eV of all isolated metabolites was acquired and compiled in a custom GC/MS library to be employed to detect metabolites in the crude extracts. MDPI 2018-04-19 /pmc/articles/PMC6017668/ /pubmed/29671776 http://dx.doi.org/10.3390/molecules23040950 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Salvatore, Maria Michela
DellaGreca, Marina
Nicoletti, Rosario
Salvatore, Francesco
Vinale, Francesco
Naviglio, Daniele
Andolfi, Anna
Talarodiolide, a New 12-Membered Macrodiolide, and GC/MS Investigation of Culture Filtrate and Mycelial Extracts of Talaromyces pinophilus
title Talarodiolide, a New 12-Membered Macrodiolide, and GC/MS Investigation of Culture Filtrate and Mycelial Extracts of Talaromyces pinophilus
title_full Talarodiolide, a New 12-Membered Macrodiolide, and GC/MS Investigation of Culture Filtrate and Mycelial Extracts of Talaromyces pinophilus
title_fullStr Talarodiolide, a New 12-Membered Macrodiolide, and GC/MS Investigation of Culture Filtrate and Mycelial Extracts of Talaromyces pinophilus
title_full_unstemmed Talarodiolide, a New 12-Membered Macrodiolide, and GC/MS Investigation of Culture Filtrate and Mycelial Extracts of Talaromyces pinophilus
title_short Talarodiolide, a New 12-Membered Macrodiolide, and GC/MS Investigation of Culture Filtrate and Mycelial Extracts of Talaromyces pinophilus
title_sort talarodiolide, a new 12-membered macrodiolide, and gc/ms investigation of culture filtrate and mycelial extracts of talaromyces pinophilus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017668/
https://www.ncbi.nlm.nih.gov/pubmed/29671776
http://dx.doi.org/10.3390/molecules23040950
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