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β-Glucans: Multi-Functional Modulator of Wound Healing
β-glucans are derived from a variety of sources including yeast, grain and fungus and belong to the class of drugs known as biological response modifiers. They possess a broad spectrum of biological activities that enhance immunity in humans. One promising area for β-glucans’ application is dermatol...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017669/ https://www.ncbi.nlm.nih.gov/pubmed/29614757 http://dx.doi.org/10.3390/molecules23040806 |
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author | Majtan, Juraj Jesenak, Milos |
author_facet | Majtan, Juraj Jesenak, Milos |
author_sort | Majtan, Juraj |
collection | PubMed |
description | β-glucans are derived from a variety of sources including yeast, grain and fungus and belong to the class of drugs known as biological response modifiers. They possess a broad spectrum of biological activities that enhance immunity in humans. One promising area for β-glucans’ application is dermatology, including wound care. Topical applications of β-glucans are increasing, especially due to their pluripotent properties. Macrophages, keratinocytes and fibroblasts are considered the main target cells of β-glucans during wound healing. β-glucans enhance wound repair by increasing the infiltration of macrophages, which stimulates tissue granulation, collagen deposition and reepithelialization. β-glucan wound dressings represent a suitable wound healing agent, with great stability and resistance to wound proteases. This review summarizes the current knowledge and progress made on characterizing β-glucans’ wound healing properties in vitro and in vivo and their safety and efficacy in managing non-healing wounds or other chronic dermatological conditions and diseases. |
format | Online Article Text |
id | pubmed-6017669 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-60176692018-11-13 β-Glucans: Multi-Functional Modulator of Wound Healing Majtan, Juraj Jesenak, Milos Molecules Review β-glucans are derived from a variety of sources including yeast, grain and fungus and belong to the class of drugs known as biological response modifiers. They possess a broad spectrum of biological activities that enhance immunity in humans. One promising area for β-glucans’ application is dermatology, including wound care. Topical applications of β-glucans are increasing, especially due to their pluripotent properties. Macrophages, keratinocytes and fibroblasts are considered the main target cells of β-glucans during wound healing. β-glucans enhance wound repair by increasing the infiltration of macrophages, which stimulates tissue granulation, collagen deposition and reepithelialization. β-glucan wound dressings represent a suitable wound healing agent, with great stability and resistance to wound proteases. This review summarizes the current knowledge and progress made on characterizing β-glucans’ wound healing properties in vitro and in vivo and their safety and efficacy in managing non-healing wounds or other chronic dermatological conditions and diseases. MDPI 2018-04-01 /pmc/articles/PMC6017669/ /pubmed/29614757 http://dx.doi.org/10.3390/molecules23040806 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Majtan, Juraj Jesenak, Milos β-Glucans: Multi-Functional Modulator of Wound Healing |
title | β-Glucans: Multi-Functional Modulator of Wound Healing |
title_full | β-Glucans: Multi-Functional Modulator of Wound Healing |
title_fullStr | β-Glucans: Multi-Functional Modulator of Wound Healing |
title_full_unstemmed | β-Glucans: Multi-Functional Modulator of Wound Healing |
title_short | β-Glucans: Multi-Functional Modulator of Wound Healing |
title_sort | β-glucans: multi-functional modulator of wound healing |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017669/ https://www.ncbi.nlm.nih.gov/pubmed/29614757 http://dx.doi.org/10.3390/molecules23040806 |
work_keys_str_mv | AT majtanjuraj bglucansmultifunctionalmodulatorofwoundhealing AT jesenakmilos bglucansmultifunctionalmodulatorofwoundhealing |