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β-Glucans: Multi-Functional Modulator of Wound Healing

β-glucans are derived from a variety of sources including yeast, grain and fungus and belong to the class of drugs known as biological response modifiers. They possess a broad spectrum of biological activities that enhance immunity in humans. One promising area for β-glucans’ application is dermatol...

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Detalles Bibliográficos
Autores principales: Majtan, Juraj, Jesenak, Milos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017669/
https://www.ncbi.nlm.nih.gov/pubmed/29614757
http://dx.doi.org/10.3390/molecules23040806
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author Majtan, Juraj
Jesenak, Milos
author_facet Majtan, Juraj
Jesenak, Milos
author_sort Majtan, Juraj
collection PubMed
description β-glucans are derived from a variety of sources including yeast, grain and fungus and belong to the class of drugs known as biological response modifiers. They possess a broad spectrum of biological activities that enhance immunity in humans. One promising area for β-glucans’ application is dermatology, including wound care. Topical applications of β-glucans are increasing, especially due to their pluripotent properties. Macrophages, keratinocytes and fibroblasts are considered the main target cells of β-glucans during wound healing. β-glucans enhance wound repair by increasing the infiltration of macrophages, which stimulates tissue granulation, collagen deposition and reepithelialization. β-glucan wound dressings represent a suitable wound healing agent, with great stability and resistance to wound proteases. This review summarizes the current knowledge and progress made on characterizing β-glucans’ wound healing properties in vitro and in vivo and their safety and efficacy in managing non-healing wounds or other chronic dermatological conditions and diseases.
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spelling pubmed-60176692018-11-13 β-Glucans: Multi-Functional Modulator of Wound Healing Majtan, Juraj Jesenak, Milos Molecules Review β-glucans are derived from a variety of sources including yeast, grain and fungus and belong to the class of drugs known as biological response modifiers. They possess a broad spectrum of biological activities that enhance immunity in humans. One promising area for β-glucans’ application is dermatology, including wound care. Topical applications of β-glucans are increasing, especially due to their pluripotent properties. Macrophages, keratinocytes and fibroblasts are considered the main target cells of β-glucans during wound healing. β-glucans enhance wound repair by increasing the infiltration of macrophages, which stimulates tissue granulation, collagen deposition and reepithelialization. β-glucan wound dressings represent a suitable wound healing agent, with great stability and resistance to wound proteases. This review summarizes the current knowledge and progress made on characterizing β-glucans’ wound healing properties in vitro and in vivo and their safety and efficacy in managing non-healing wounds or other chronic dermatological conditions and diseases. MDPI 2018-04-01 /pmc/articles/PMC6017669/ /pubmed/29614757 http://dx.doi.org/10.3390/molecules23040806 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Majtan, Juraj
Jesenak, Milos
β-Glucans: Multi-Functional Modulator of Wound Healing
title β-Glucans: Multi-Functional Modulator of Wound Healing
title_full β-Glucans: Multi-Functional Modulator of Wound Healing
title_fullStr β-Glucans: Multi-Functional Modulator of Wound Healing
title_full_unstemmed β-Glucans: Multi-Functional Modulator of Wound Healing
title_short β-Glucans: Multi-Functional Modulator of Wound Healing
title_sort β-glucans: multi-functional modulator of wound healing
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017669/
https://www.ncbi.nlm.nih.gov/pubmed/29614757
http://dx.doi.org/10.3390/molecules23040806
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