A New Lignanamide from the Root of Lycium yunnanense Kuang and Its Antioxidant Activity

A new lignanamide (1), lyciumamide K, together with four known analogues (2–5), was isolated from the root of Lycium yunnanense Kuang. Based on HR-ESI-MS, NMR spectral data and quantum chemistry ECD calculations, the structure of this new compound was confirmed, including its absolute configuration....

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Detalles Bibliográficos
Autores principales: Zheng, Xin-Heng, Huang, Yuan-Peng, Liang, Qiu-Ping, Xu, Wei, Lan, Ting, Zhou, Guang-Xiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017700/
https://www.ncbi.nlm.nih.gov/pubmed/29584684
http://dx.doi.org/10.3390/molecules23040770
Descripción
Sumario:A new lignanamide (1), lyciumamide K, together with four known analogues (2–5), was isolated from the root of Lycium yunnanense Kuang. Based on HR-ESI-MS, NMR spectral data and quantum chemistry ECD calculations, the structure of this new compound was confirmed, including its absolute configuration. Evaluation of the antioxidant activity of compounds 1–5 in the oxygen radical absorption capacity (ORAC) assay showed that they all exhibited significant antioxidant activities. Particularly, compound 1 showed the best activity with ORAC values (U/mol) of 7.90 ± 0.52. Thus, the new lignanamide may be a good source of bioavtive and protective compounds.

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