A New Lignanamide from the Root of Lycium yunnanense Kuang and Its Antioxidant Activity

A new lignanamide (1), lyciumamide K, together with four known analogues (2–5), was isolated from the root of Lycium yunnanense Kuang. Based on HR-ESI-MS, NMR spectral data and quantum chemistry ECD calculations, the structure of this new compound was confirmed, including its absolute configuration....

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Autores principales: Zheng, Xin-Heng, Huang, Yuan-Peng, Liang, Qiu-Ping, Xu, Wei, Lan, Ting, Zhou, Guang-Xiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017700/
https://www.ncbi.nlm.nih.gov/pubmed/29584684
http://dx.doi.org/10.3390/molecules23040770
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author Zheng, Xin-Heng
Huang, Yuan-Peng
Liang, Qiu-Ping
Xu, Wei
Lan, Ting
Zhou, Guang-Xiong
author_facet Zheng, Xin-Heng
Huang, Yuan-Peng
Liang, Qiu-Ping
Xu, Wei
Lan, Ting
Zhou, Guang-Xiong
author_sort Zheng, Xin-Heng
collection PubMed
description A new lignanamide (1), lyciumamide K, together with four known analogues (2–5), was isolated from the root of Lycium yunnanense Kuang. Based on HR-ESI-MS, NMR spectral data and quantum chemistry ECD calculations, the structure of this new compound was confirmed, including its absolute configuration. Evaluation of the antioxidant activity of compounds 1–5 in the oxygen radical absorption capacity (ORAC) assay showed that they all exhibited significant antioxidant activities. Particularly, compound 1 showed the best activity with ORAC values (U/mol) of 7.90 ± 0.52. Thus, the new lignanamide may be a good source of bioavtive and protective compounds.
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spelling pubmed-60177002018-11-13 A New Lignanamide from the Root of Lycium yunnanense Kuang and Its Antioxidant Activity Zheng, Xin-Heng Huang, Yuan-Peng Liang, Qiu-Ping Xu, Wei Lan, Ting Zhou, Guang-Xiong Molecules Article A new lignanamide (1), lyciumamide K, together with four known analogues (2–5), was isolated from the root of Lycium yunnanense Kuang. Based on HR-ESI-MS, NMR spectral data and quantum chemistry ECD calculations, the structure of this new compound was confirmed, including its absolute configuration. Evaluation of the antioxidant activity of compounds 1–5 in the oxygen radical absorption capacity (ORAC) assay showed that they all exhibited significant antioxidant activities. Particularly, compound 1 showed the best activity with ORAC values (U/mol) of 7.90 ± 0.52. Thus, the new lignanamide may be a good source of bioavtive and protective compounds. MDPI 2018-03-27 /pmc/articles/PMC6017700/ /pubmed/29584684 http://dx.doi.org/10.3390/molecules23040770 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zheng, Xin-Heng
Huang, Yuan-Peng
Liang, Qiu-Ping
Xu, Wei
Lan, Ting
Zhou, Guang-Xiong
A New Lignanamide from the Root of Lycium yunnanense Kuang and Its Antioxidant Activity
title A New Lignanamide from the Root of Lycium yunnanense Kuang and Its Antioxidant Activity
title_full A New Lignanamide from the Root of Lycium yunnanense Kuang and Its Antioxidant Activity
title_fullStr A New Lignanamide from the Root of Lycium yunnanense Kuang and Its Antioxidant Activity
title_full_unstemmed A New Lignanamide from the Root of Lycium yunnanense Kuang and Its Antioxidant Activity
title_short A New Lignanamide from the Root of Lycium yunnanense Kuang and Its Antioxidant Activity
title_sort new lignanamide from the root of lycium yunnanense kuang and its antioxidant activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017700/
https://www.ncbi.nlm.nih.gov/pubmed/29584684
http://dx.doi.org/10.3390/molecules23040770
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