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Identification of Bichalcones as Sirtuin Inhibitors by Virtual Screening and In Vitro Testing
Sirtuins are nicotinamide adenine dinucleotide (NAD(+))-dependent class III histone deacetylases, which have been linked to the pathogenesis of numerous diseases, including HIV, metabolic disorders, neurodegeneration and cancer. Docking of the virtual pan-African natural products library (p-ANAPL),...
Autores principales: | Karaman, Berin, Alhalabi, Zayan, Swyter, Sören, Mihigo, Shetonde O., Andrae-Marobela, Kerstin, Jung, Manfred, Sippl, Wolfgang, Ntie-Kang, Fidele |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017733/ https://www.ncbi.nlm.nih.gov/pubmed/29443909 http://dx.doi.org/10.3390/molecules23020416 |
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