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Novel Semisynthetic Derivatives of Bile Acids as Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibitors

An Important task in the treatment of oncological and neurodegenerative diseases is the search for new inhibitors of DNA repair system enzymes. Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is one of the DNA repair system enzymes involved in the removal of DNA damages caused by topoisomerase I inhibitors....

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Detalles Bibliográficos
Autores principales:	Salomatina, Oksana V., Popadyuk, Irina I., Zakharenko, Alexandra L., Zakharova, Olga D., Fadeev, Dmitriy S., Komarova, Nina I., Reynisson, Jóhannes, Arabshahi, H. John, Chand, Raina, Volcho, Konstantin P., Salakhutdinov, Nariman F., Lavrik, Olga I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017735/ https://www.ncbi.nlm.nih.gov/pubmed/29562592 http://dx.doi.org/10.3390/molecules23030679

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