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Synthesis, Structural Characterization and Antimicrobial Activity of Cu(II) and Fe(III) Complexes Incorporating Azo-Azomethine Ligand

We are reporting a novel azo-azomethine ligand, HL and its complexes with Cu(II) and Fe(III) ions. The ligand and its complexes are characterized by various physico-chemical techniques using C,H,N analyses, FT-IR, (1)H-NMR, ESI-MS and UV-Vis studies. TGA analyses reveal complexes are sufficiently st...

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Autores principales: Azam, Mohammad, Al-Resayes, Saud I., Wabaidur, Saikh Mohammad, Altaf, Mohammad, Chaurasia, Bhaskar, Alam, Mahboob, Shukla, Satyendra Nath, Gaur, Pratiksha, Albaqami, Nader Talmas M., Islam, Mohammad Shahidul, Park, Soonheum
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017743/
https://www.ncbi.nlm.nih.gov/pubmed/29614828
http://dx.doi.org/10.3390/molecules23040813
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author Azam, Mohammad
Al-Resayes, Saud I.
Wabaidur, Saikh Mohammad
Altaf, Mohammad
Chaurasia, Bhaskar
Alam, Mahboob
Shukla, Satyendra Nath
Gaur, Pratiksha
Albaqami, Nader Talmas M.
Islam, Mohammad Shahidul
Park, Soonheum
author_facet Azam, Mohammad
Al-Resayes, Saud I.
Wabaidur, Saikh Mohammad
Altaf, Mohammad
Chaurasia, Bhaskar
Alam, Mahboob
Shukla, Satyendra Nath
Gaur, Pratiksha
Albaqami, Nader Talmas M.
Islam, Mohammad Shahidul
Park, Soonheum
author_sort Azam, Mohammad
collection PubMed
description We are reporting a novel azo-azomethine ligand, HL and its complexes with Cu(II) and Fe(III) ions. The ligand and its complexes are characterized by various physico-chemical techniques using C,H,N analyses, FT-IR, (1)H-NMR, ESI-MS and UV-Vis studies. TGA analyses reveal complexes are sufficiently stable and undergo two-step degradation processes. The redox behavior of the complexes was evaluated by cyclic voltammetry. Furthermore, the ligand and its complexes were tested for antimicrobial activity against bacterial and fungal strains by determining inhibition zone, minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC). The complexes showed moderate antimicrobial activity when tested against Gram +ve and Gram −ve bacterial strains. To obtain insights into the structure of ligand, DFT studies are recorded. The results obtained are quite close to the experimental results. In addition, the energy gap, chemical hardness, softness, electronegativity, electrophilic index and chemical potential were calculated using HOMO, LUMO energy value of ligand.
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spelling pubmed-60177432018-11-13 Synthesis, Structural Characterization and Antimicrobial Activity of Cu(II) and Fe(III) Complexes Incorporating Azo-Azomethine Ligand Azam, Mohammad Al-Resayes, Saud I. Wabaidur, Saikh Mohammad Altaf, Mohammad Chaurasia, Bhaskar Alam, Mahboob Shukla, Satyendra Nath Gaur, Pratiksha Albaqami, Nader Talmas M. Islam, Mohammad Shahidul Park, Soonheum Molecules Article We are reporting a novel azo-azomethine ligand, HL and its complexes with Cu(II) and Fe(III) ions. The ligand and its complexes are characterized by various physico-chemical techniques using C,H,N analyses, FT-IR, (1)H-NMR, ESI-MS and UV-Vis studies. TGA analyses reveal complexes are sufficiently stable and undergo two-step degradation processes. The redox behavior of the complexes was evaluated by cyclic voltammetry. Furthermore, the ligand and its complexes were tested for antimicrobial activity against bacterial and fungal strains by determining inhibition zone, minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC). The complexes showed moderate antimicrobial activity when tested against Gram +ve and Gram −ve bacterial strains. To obtain insights into the structure of ligand, DFT studies are recorded. The results obtained are quite close to the experimental results. In addition, the energy gap, chemical hardness, softness, electronegativity, electrophilic index and chemical potential were calculated using HOMO, LUMO energy value of ligand. MDPI 2018-04-02 /pmc/articles/PMC6017743/ /pubmed/29614828 http://dx.doi.org/10.3390/molecules23040813 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Azam, Mohammad
Al-Resayes, Saud I.
Wabaidur, Saikh Mohammad
Altaf, Mohammad
Chaurasia, Bhaskar
Alam, Mahboob
Shukla, Satyendra Nath
Gaur, Pratiksha
Albaqami, Nader Talmas M.
Islam, Mohammad Shahidul
Park, Soonheum
Synthesis, Structural Characterization and Antimicrobial Activity of Cu(II) and Fe(III) Complexes Incorporating Azo-Azomethine Ligand
title Synthesis, Structural Characterization and Antimicrobial Activity of Cu(II) and Fe(III) Complexes Incorporating Azo-Azomethine Ligand
title_full Synthesis, Structural Characterization and Antimicrobial Activity of Cu(II) and Fe(III) Complexes Incorporating Azo-Azomethine Ligand
title_fullStr Synthesis, Structural Characterization and Antimicrobial Activity of Cu(II) and Fe(III) Complexes Incorporating Azo-Azomethine Ligand
title_full_unstemmed Synthesis, Structural Characterization and Antimicrobial Activity of Cu(II) and Fe(III) Complexes Incorporating Azo-Azomethine Ligand
title_short Synthesis, Structural Characterization and Antimicrobial Activity of Cu(II) and Fe(III) Complexes Incorporating Azo-Azomethine Ligand
title_sort synthesis, structural characterization and antimicrobial activity of cu(ii) and fe(iii) complexes incorporating azo-azomethine ligand
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017743/
https://www.ncbi.nlm.nih.gov/pubmed/29614828
http://dx.doi.org/10.3390/molecules23040813
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