Cargando…
Synthesis, Structural Characterization and Antimicrobial Activity of Cu(II) and Fe(III) Complexes Incorporating Azo-Azomethine Ligand
We are reporting a novel azo-azomethine ligand, HL and its complexes with Cu(II) and Fe(III) ions. The ligand and its complexes are characterized by various physico-chemical techniques using C,H,N analyses, FT-IR, (1)H-NMR, ESI-MS and UV-Vis studies. TGA analyses reveal complexes are sufficiently st...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017743/ https://www.ncbi.nlm.nih.gov/pubmed/29614828 http://dx.doi.org/10.3390/molecules23040813 |
_version_ | 1783334815205949440 |
---|---|
author | Azam, Mohammad Al-Resayes, Saud I. Wabaidur, Saikh Mohammad Altaf, Mohammad Chaurasia, Bhaskar Alam, Mahboob Shukla, Satyendra Nath Gaur, Pratiksha Albaqami, Nader Talmas M. Islam, Mohammad Shahidul Park, Soonheum |
author_facet | Azam, Mohammad Al-Resayes, Saud I. Wabaidur, Saikh Mohammad Altaf, Mohammad Chaurasia, Bhaskar Alam, Mahboob Shukla, Satyendra Nath Gaur, Pratiksha Albaqami, Nader Talmas M. Islam, Mohammad Shahidul Park, Soonheum |
author_sort | Azam, Mohammad |
collection | PubMed |
description | We are reporting a novel azo-azomethine ligand, HL and its complexes with Cu(II) and Fe(III) ions. The ligand and its complexes are characterized by various physico-chemical techniques using C,H,N analyses, FT-IR, (1)H-NMR, ESI-MS and UV-Vis studies. TGA analyses reveal complexes are sufficiently stable and undergo two-step degradation processes. The redox behavior of the complexes was evaluated by cyclic voltammetry. Furthermore, the ligand and its complexes were tested for antimicrobial activity against bacterial and fungal strains by determining inhibition zone, minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC). The complexes showed moderate antimicrobial activity when tested against Gram +ve and Gram −ve bacterial strains. To obtain insights into the structure of ligand, DFT studies are recorded. The results obtained are quite close to the experimental results. In addition, the energy gap, chemical hardness, softness, electronegativity, electrophilic index and chemical potential were calculated using HOMO, LUMO energy value of ligand. |
format | Online Article Text |
id | pubmed-6017743 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-60177432018-11-13 Synthesis, Structural Characterization and Antimicrobial Activity of Cu(II) and Fe(III) Complexes Incorporating Azo-Azomethine Ligand Azam, Mohammad Al-Resayes, Saud I. Wabaidur, Saikh Mohammad Altaf, Mohammad Chaurasia, Bhaskar Alam, Mahboob Shukla, Satyendra Nath Gaur, Pratiksha Albaqami, Nader Talmas M. Islam, Mohammad Shahidul Park, Soonheum Molecules Article We are reporting a novel azo-azomethine ligand, HL and its complexes with Cu(II) and Fe(III) ions. The ligand and its complexes are characterized by various physico-chemical techniques using C,H,N analyses, FT-IR, (1)H-NMR, ESI-MS and UV-Vis studies. TGA analyses reveal complexes are sufficiently stable and undergo two-step degradation processes. The redox behavior of the complexes was evaluated by cyclic voltammetry. Furthermore, the ligand and its complexes were tested for antimicrobial activity against bacterial and fungal strains by determining inhibition zone, minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC). The complexes showed moderate antimicrobial activity when tested against Gram +ve and Gram −ve bacterial strains. To obtain insights into the structure of ligand, DFT studies are recorded. The results obtained are quite close to the experimental results. In addition, the energy gap, chemical hardness, softness, electronegativity, electrophilic index and chemical potential were calculated using HOMO, LUMO energy value of ligand. MDPI 2018-04-02 /pmc/articles/PMC6017743/ /pubmed/29614828 http://dx.doi.org/10.3390/molecules23040813 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Azam, Mohammad Al-Resayes, Saud I. Wabaidur, Saikh Mohammad Altaf, Mohammad Chaurasia, Bhaskar Alam, Mahboob Shukla, Satyendra Nath Gaur, Pratiksha Albaqami, Nader Talmas M. Islam, Mohammad Shahidul Park, Soonheum Synthesis, Structural Characterization and Antimicrobial Activity of Cu(II) and Fe(III) Complexes Incorporating Azo-Azomethine Ligand |
title | Synthesis, Structural Characterization and Antimicrobial Activity of Cu(II) and Fe(III) Complexes Incorporating Azo-Azomethine Ligand |
title_full | Synthesis, Structural Characterization and Antimicrobial Activity of Cu(II) and Fe(III) Complexes Incorporating Azo-Azomethine Ligand |
title_fullStr | Synthesis, Structural Characterization and Antimicrobial Activity of Cu(II) and Fe(III) Complexes Incorporating Azo-Azomethine Ligand |
title_full_unstemmed | Synthesis, Structural Characterization and Antimicrobial Activity of Cu(II) and Fe(III) Complexes Incorporating Azo-Azomethine Ligand |
title_short | Synthesis, Structural Characterization and Antimicrobial Activity of Cu(II) and Fe(III) Complexes Incorporating Azo-Azomethine Ligand |
title_sort | synthesis, structural characterization and antimicrobial activity of cu(ii) and fe(iii) complexes incorporating azo-azomethine ligand |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017743/ https://www.ncbi.nlm.nih.gov/pubmed/29614828 http://dx.doi.org/10.3390/molecules23040813 |
work_keys_str_mv | AT azammohammad synthesisstructuralcharacterizationandantimicrobialactivityofcuiiandfeiiicomplexesincorporatingazoazomethineligand AT alresayessaudi synthesisstructuralcharacterizationandantimicrobialactivityofcuiiandfeiiicomplexesincorporatingazoazomethineligand AT wabaidursaikhmohammad synthesisstructuralcharacterizationandantimicrobialactivityofcuiiandfeiiicomplexesincorporatingazoazomethineligand AT altafmohammad synthesisstructuralcharacterizationandantimicrobialactivityofcuiiandfeiiicomplexesincorporatingazoazomethineligand AT chaurasiabhaskar synthesisstructuralcharacterizationandantimicrobialactivityofcuiiandfeiiicomplexesincorporatingazoazomethineligand AT alammahboob synthesisstructuralcharacterizationandantimicrobialactivityofcuiiandfeiiicomplexesincorporatingazoazomethineligand AT shuklasatyendranath synthesisstructuralcharacterizationandantimicrobialactivityofcuiiandfeiiicomplexesincorporatingazoazomethineligand AT gaurpratiksha synthesisstructuralcharacterizationandantimicrobialactivityofcuiiandfeiiicomplexesincorporatingazoazomethineligand AT albaqaminadertalmasm synthesisstructuralcharacterizationandantimicrobialactivityofcuiiandfeiiicomplexesincorporatingazoazomethineligand AT islammohammadshahidul synthesisstructuralcharacterizationandantimicrobialactivityofcuiiandfeiiicomplexesincorporatingazoazomethineligand AT parksoonheum synthesisstructuralcharacterizationandantimicrobialactivityofcuiiandfeiiicomplexesincorporatingazoazomethineligand |