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Structural Dynamics of DPP-4 and Its Influence on the Projection of Bioactive Ligands

Dipeptidyl peptidase-4 (DPP-4) is a target to treat type II diabetes mellitus. Therefore, it is important to understand the structural aspects of this enzyme and its interaction with drug candidates. This study involved molecular dynamics simulations, normal mode analysis, binding site detection and...

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Detalles Bibliográficos
Autores principales:	Pantaleão, Simone Queiroz, Philot, Eric Allison, de Resende-Lara, Pedro Túlio, Lima, Angélica Nakagawa, Perahia, David, Miteva, Maria Atanassova, Scott, Ana Ligia, Honorio, Kathia Maria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017819/ https://www.ncbi.nlm.nih.gov/pubmed/29473857 http://dx.doi.org/10.3390/molecules23020490

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