A Greener and Efficient Method for Nucleophilic Aromatic Substitution of Nitrogen-Containing Fused Heterocycles

A simple and efficient methodology for the nucleophilic aromatic substitution of nitrogen-containing fused heterocycles with interesting biological activities has been developed in an environmentally sound manner using polyethylene glycol (PEG-400) as the solvent, leading to the expected compounds i...

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Autores principales: Campos, Joana F., Loubidi, Mohammed, Scherrmann, Marie-Christine, Berteina-Raboin, Sabine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017854/
https://www.ncbi.nlm.nih.gov/pubmed/29562645
http://dx.doi.org/10.3390/molecules23030684
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author Campos, Joana F.
Loubidi, Mohammed
Scherrmann, Marie-Christine
Berteina-Raboin, Sabine
author_facet Campos, Joana F.
Loubidi, Mohammed
Scherrmann, Marie-Christine
Berteina-Raboin, Sabine
author_sort Campos, Joana F.
collection PubMed
description A simple and efficient methodology for the nucleophilic aromatic substitution of nitrogen-containing fused heterocycles with interesting biological activities has been developed in an environmentally sound manner using polyethylene glycol (PEG-400) as the solvent, leading to the expected compounds in excellent yields in only five minutes.
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spelling pubmed-60178542018-11-13 A Greener and Efficient Method for Nucleophilic Aromatic Substitution of Nitrogen-Containing Fused Heterocycles Campos, Joana F. Loubidi, Mohammed Scherrmann, Marie-Christine Berteina-Raboin, Sabine Molecules Article A simple and efficient methodology for the nucleophilic aromatic substitution of nitrogen-containing fused heterocycles with interesting biological activities has been developed in an environmentally sound manner using polyethylene glycol (PEG-400) as the solvent, leading to the expected compounds in excellent yields in only five minutes. MDPI 2018-03-18 /pmc/articles/PMC6017854/ /pubmed/29562645 http://dx.doi.org/10.3390/molecules23030684 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Campos, Joana F.
Loubidi, Mohammed
Scherrmann, Marie-Christine
Berteina-Raboin, Sabine
A Greener and Efficient Method for Nucleophilic Aromatic Substitution of Nitrogen-Containing Fused Heterocycles
title A Greener and Efficient Method for Nucleophilic Aromatic Substitution of Nitrogen-Containing Fused Heterocycles
title_full A Greener and Efficient Method for Nucleophilic Aromatic Substitution of Nitrogen-Containing Fused Heterocycles
title_fullStr A Greener and Efficient Method for Nucleophilic Aromatic Substitution of Nitrogen-Containing Fused Heterocycles
title_full_unstemmed A Greener and Efficient Method for Nucleophilic Aromatic Substitution of Nitrogen-Containing Fused Heterocycles
title_short A Greener and Efficient Method for Nucleophilic Aromatic Substitution of Nitrogen-Containing Fused Heterocycles
title_sort greener and efficient method for nucleophilic aromatic substitution of nitrogen-containing fused heterocycles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017854/
https://www.ncbi.nlm.nih.gov/pubmed/29562645
http://dx.doi.org/10.3390/molecules23030684
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