Cargando…

Flaccidoxide-13-Acetate Extracted from the Soft Coral Cladiella kashmani Reduces Human Bladder Cancer Cell Migration and Invasion through Reducing Activation of the FAK/PI3K/AKT/mTOR Signaling Pathway

Metastasis of cancer is the cause of the majority of cancer deaths. Active compound flaccidoxide-13-acetate, isolated from the soft coral Cladiella kashmani, has been found to exhibit anti-tumor activity. In this study, Boyden chamber analysis, Western blotting and gelatin zymography assays indicate...

Descripción completa

Detalles Bibliográficos
Autores principales:	Neoh, Choo-Aun, Wu, Wen-Tung, Dai, Guo-Fong, Su, Jui-Hsin, Liu, Chih-I, Su, Tzu-Rong, Wu, Yu-Jen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017900/ https://www.ncbi.nlm.nih.gov/pubmed/29280977 http://dx.doi.org/10.3390/molecules23010058

Ejemplares similares

Exploring the Mechanism of Flaccidoxide-13-Acetate in Suppressing Cell Metastasis of Hepatocellular Carcinoma
por: Wu, Yu-Jen, et al.
Publicado: (2020)

Flaccidoxide-13-Acetate-Induced Apoptosis in Human Bladder Cancer Cells is through Activation of p38/JNK, Mitochondrial Dysfunction, and Endoplasmic Reticulum Stress Regulated Pathway
por: Wu, Yu-Jen, et al.
Publicado: (2019)

Bioactive Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi
por: Tai, Chi-Jen, et al.
Publicado: (2011)

Eunicellin-Based Diterpenoids, Hirsutalins S–V, from the Formosan Soft Coral Cladiella hirsuta
por: Huang, Tzu-Zin, et al.
Publicado: (2015)

Cytotoxic and Anti-Inflammatory Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi
por: Tai, Chi-Jen, et al.
Publicado: (2013)

Krempfielins Q and R, Two New Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi
por: Tai, Chi-Jen, et al.
Publicado: (2014)

Discovery of New Eunicellin-Based Diterpenoids from a Formosan Soft Coral Cladiella sp.
por: Chen, Tsung-Hung, et al.
Publicado: (2013)

Eunicellin-Based Diterpenoids, Hirsutalins N–R, from the Formosan Soft Coral Cladiella hirsuta
por: Huang, Tzu-Zin, et al.
Publicado: (2014)

11-epi-Sinulariolide Acetate Reduces Cell Migration and Invasion of Human Hepatocellular Carcinoma by Reducing the Activation of ERK1/2, p38MAPK and FAK/PI3K/AKT/mTOR Signaling Pathways
por: Lin, Jen-Jie, et al.
Publicado: (2014)

Discovery of New Eunicellins from an Indonesian Octocoral Cladiella sp.
por: Chen, Yung-Husan, et al.
Publicado: (2011)

Stellettin B Isolated from Stelletta Sp. Reduces Migration and Invasion of Hepatocellular Carcinoma Cells through Reducing Activation of the MAPKs and FAK/PI3K/AKT/mTOR Signaling Pathways
por: Tsai, Tsung-Chang, et al.
Publicado: (2022)

Krempfielins J–M, New Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi
por: Lee, Yan-Ning, et al.
Publicado: (2013)

Krempfielins N–P, New Anti-Inflammatory Eunicellins from a Taiwanese Soft Coral Cladiella krempfi
por: Lee, Yan-Ning, et al.
Publicado: (2014)

Cladieunicellins M–Q, New Eunicellins from Cladiella sp.
por: Chen, Tsung-Hung, et al.
Publicado: (2014)

Involvement of Mitochondrial Dysfunction, Endoplasmic Reticulum Stress, and the PI3K/AKT/mTOR Pathway in Nobiletin-Induced Apoptosis of Human Bladder Cancer Cells
por: Goan, Yih-Gang, et al.
Publicado: (2019)

Induction of Apoptosis by Sinulariolide from Soft Coral through Mitochondrial-Related and p38MAPK Pathways on Human Bladder Carcinoma Cells
por: Neoh, Choo-Aun, et al.
Publicado: (2012)

Anticancer Potential of Green Synthesized Silver Nanoparticles of the Soft Coral Cladiella pachyclados Supported by Network Pharmacology and In Silico Analyses
por: Alhadrami, Hani A., et al.
Publicado: (2021)

Sinulariolide Suppresses Human Hepatocellular Carcinoma Cell Migration and Invasion by Inhibiting Matrix Metalloproteinase-2/-9 through MAPKs and PI3K/Akt Signaling Pathways
por: Wu, Yu-Jen, et al.
Publicado: (2015)

New Cladiellin-Type Diterpenoids from the South China Sea Soft Coral Cladiella krempfi: Structures and Molecular Docking Analysis in EGFRs
por: Jin, Yang, et al.
Publicado: (2022)

Cladieunicellins K and L, New Eunicellin-Based Diterpenoids from an Octocoral Cladiella sp
por: Shih, Fu-Yuan, et al.
Publicado: (2013)

Extracts from Cladiella australis, Clavularia viridis and Klyxum simplex (Soft Corals) are Capable of Inhibiting the Growth of Human Oral Squamous Cell Carcinoma Cells
por: Liang, Chia-Hua, et al.
Publicado: (2008)

Sinulariolide Inhibits Gastric Cancer Cell Migration and Invasion through Downregulation of the EMT Process and Suppression of FAK/PI3K/AKT/mTOR and MAPKs Signaling Pathways
por: Wu, Yu-Jen, et al.
Publicado: (2019)

Cladielloides A and B: New Eunicellin-Type Diterpenoids from an Indonesian Octocoral Cladiella sp
por: Chen, Yung-Husan, et al.
Publicado: (2010)

Biodegradable Stent with mTOR Inhibitor-Eluting Reduces Progression of Ureteral Stricture
por: Ho, Dong-Ru, et al.
Publicado: (2021)

Bornyl cis-4-Hydroxycinnamate Suppresses Cell Metastasis of Melanoma through FAK/PI3K/Akt/mTOR and MAPK Signaling Pathways and Inhibition of the Epithelial-to-Mesenchymal Transition
por: Yang, Tzu-Yen, et al.
Publicado: (2018)

Synergism between the mTOR inhibitor rapamycin and FAK down-regulation in the treatment of acute lymphoblastic leukemia
por: Shi, Pei-Jie, et al.
Publicado: (2016)

Induction of Apoptosis and Effect on the FAK/AKT/mTOR Signal Pathway by Evodiamine in Gastric Cancer Cells
por: Yang, Ji Yeong, et al.
Publicado: (2022)

Altering FAK-Paxillin Interactions Reduces Adhesion, Migration and Invasion Processes
por: Deramaudt, Thérèse B., et al.
Publicado: (2014)

mTOR inhibitor everolimus reduces invasiveness of melanoma cells
por: Ciołczyk-Wierzbicka, Dorota, et al.
Publicado: (2019)

Oxygenated Cembranoids from the Soft Coral Sinularia flexibilis
por: Su, Ching-Chyuan, et al.
Publicado: (2013)

Local Stressors Reduce Coral Resilience to Bleaching
por: Carilli, Jessica E., et al.
Publicado: (2009)

Gephyrin suppresses lung squamous cell carcinoma development by reducing mTOR pathway activation
por: Zhang, Xiang, et al.
Publicado: (2019)

Inhibition of mTOR Reduces Anal Carcinogenesis in Transgenic Mouse Model
por: Sun, Zhi-Jun, et al.
Publicado: (2013)

Comparisons of Prediction Models of Myofascial Pain Control after Dry Needling: A Prospective Study
por: Huang, Yuan-Ting, et al.
Publicado: (2013)

Sanguinarine inhibits melanoma invasion and migration by targeting the FAK/PI3K/AKT/mTOR signalling pathway
por: Qi, Xiaoyi, et al.
Publicado: (2023)

A High Resolution Computer Tomography Scoring System to Predict Culture-Positive Pulmonary Tuberculosis in the Emergency Department
por: Yeh, Jun -Jun, et al.
Publicado: (2014)

Galectin-1 Overexpression Activates the FAK/PI3K/AKT/mTOR Pathway and Is Correlated with Upper Urinary Urothelial Carcinoma Progression and Survival
por: Su, Yu-Li, et al.
Publicado: (2020)

A Soft Coral-Derived Compound, 11-epi-Sinulariolide Acetate Suppresses Inflammatory Response and Bone Destruction in Adjuvant-Induced Arthritis
por: Lin, Yen-You, et al.
Publicado: (2013)

FAK inhibition alone or in combination with adjuvant therapies reduces cancer stem cell activity
por: Timbrell, Simon, et al.
Publicado: (2021)

Toxic coral gobies reduce the feeding rate of a corallivorous butterflyfish on Acropora corals
por: Dirnwoeber, M., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_1m6ts5d8pppep1ln63ukdcmd98