Huberine, a New Canthin-6-One Alkaloid from the Bark of Picrolemma huberi

A new alkaloid, Canthin-6-one, Huberine (1), together with three known compounds including 1-Hydroxy-canthin-6-one (2), Canthin-6-one (3) and stigma sterol (4), were isolated from the stem bark of Picrolemma huberi. The isolation was achieved by chromatographic techniques and the purification was pe...

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Autores principales: López, Carlos, Pastrana, Manuel, Ríos, Alexandra, Cogollo, Alvaro, Pabón, Adriana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017910/
https://www.ncbi.nlm.nih.gov/pubmed/29673229
http://dx.doi.org/10.3390/molecules23040934
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author López, Carlos
Pastrana, Manuel
Ríos, Alexandra
Cogollo, Alvaro
Pabón, Adriana
author_facet López, Carlos
Pastrana, Manuel
Ríos, Alexandra
Cogollo, Alvaro
Pabón, Adriana
author_sort López, Carlos
collection PubMed
description A new alkaloid, Canthin-6-one, Huberine (1), together with three known compounds including 1-Hydroxy-canthin-6-one (2), Canthin-6-one (3) and stigma sterol (4), were isolated from the stem bark of Picrolemma huberi. The isolation was achieved by chromatographic techniques and the purification was performed on a C18 column using acetonitrile/water (90:10, v/v) with 0.1% formic acid as the mobile phase. The structural elucidation was performed via spectroscopic methods, notably 1D- and 2D-NMR, UV, IR, MS and HRMS. The antiplasmodial activity of the compounds was studied.
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spelling pubmed-60179102018-11-13 Huberine, a New Canthin-6-One Alkaloid from the Bark of Picrolemma huberi López, Carlos Pastrana, Manuel Ríos, Alexandra Cogollo, Alvaro Pabón, Adriana Molecules Article A new alkaloid, Canthin-6-one, Huberine (1), together with three known compounds including 1-Hydroxy-canthin-6-one (2), Canthin-6-one (3) and stigma sterol (4), were isolated from the stem bark of Picrolemma huberi. The isolation was achieved by chromatographic techniques and the purification was performed on a C18 column using acetonitrile/water (90:10, v/v) with 0.1% formic acid as the mobile phase. The structural elucidation was performed via spectroscopic methods, notably 1D- and 2D-NMR, UV, IR, MS and HRMS. The antiplasmodial activity of the compounds was studied. MDPI 2018-04-17 /pmc/articles/PMC6017910/ /pubmed/29673229 http://dx.doi.org/10.3390/molecules23040934 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
López, Carlos
Pastrana, Manuel
Ríos, Alexandra
Cogollo, Alvaro
Pabón, Adriana
Huberine, a New Canthin-6-One Alkaloid from the Bark of Picrolemma huberi
title Huberine, a New Canthin-6-One Alkaloid from the Bark of Picrolemma huberi
title_full Huberine, a New Canthin-6-One Alkaloid from the Bark of Picrolemma huberi
title_fullStr Huberine, a New Canthin-6-One Alkaloid from the Bark of Picrolemma huberi
title_full_unstemmed Huberine, a New Canthin-6-One Alkaloid from the Bark of Picrolemma huberi
title_short Huberine, a New Canthin-6-One Alkaloid from the Bark of Picrolemma huberi
title_sort huberine, a new canthin-6-one alkaloid from the bark of picrolemma huberi
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017910/
https://www.ncbi.nlm.nih.gov/pubmed/29673229
http://dx.doi.org/10.3390/molecules23040934
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