Sensitive Detection of 8-Nitroguanine in DNA by Chemical Derivatization Coupled with Online Solid-Phase Extraction LC-MS/MS

8-Nitroguanine (8-nitroG) is a major mutagenic nucleobase lesion generated by peroxynitrite during inflammation and has been used as a potential biomarker to evaluate inflammation-related carcinogenesis. Here, we present an online solid-phase extraction (SPE) LC-MS/MS method with 6-methoxy-2-naphthy...

Descripción completa

Detalles Bibliográficos
Autores principales: Hu, Chiung-Wen, Chang, Yuan-Jhe, Chen, Jian-Lian, Hsu, Yu-Wen, Chao, Mu-Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017919/
https://www.ncbi.nlm.nih.gov/pubmed/29517997
http://dx.doi.org/10.3390/molecules23030605

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017919/
https://www.ncbi.nlm.nih.gov/pubmed/29517997
http://dx.doi.org/10.3390/molecules23030605

Ejemplares similares