Cargando…

Informing Efforts to Develop Nitroreductase for Amine Production

Nitroreductases (NRs) hold promise for converting nitroaromatics to aromatic amines. Nitroaromatic reduction rate increases with Hammett substituent constant for NRs from two different subgroups, confirming substrate identity as a key determinant of reactivity. Amine yields were low, but compounds y...

Descripción completa

Detalles Bibliográficos
Autores principales:	Miller, Anne-Frances, Park, Jonathan T., Ferguson, Kyle L., Pitsawong, Warintra, Bommarius, Andreas S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017928/ https://www.ncbi.nlm.nih.gov/pubmed/29364838 http://dx.doi.org/10.3390/molecules23020211

Ejemplares similares

Nitroreductase Activites in Giardia lamblia: ORF 17150 Encodes a Quinone Reductase with Nitroreductase Activity
por: Müller, Joachim, et al.
Publicado: (2021)

Evolutionary aspects of the Viridiplantae nitroreductases
por: Dabravolski, Siarhei A.
Publicado: (2020)

The Role of Nitroreductases in Resistance to Nitroimidazoles
por: Thomas, Carol, et al.
Publicado: (2021)

Development of a Bioluminescent Nitroreductase Probe for Preclinical Imaging
por: Vorobyeva, Anzhelika G., et al.
Publicado: (2015)

Realizing the Continuous Chemoenzymatic Synthesis of Anilines Using an Immobilized Nitroreductase
por: Cosgrove, Sebastian C., et al.
Publicado: (2023)

Mechanism of activating mutations and allosteric drug inhibition of the phosphatase SHP2
por: Pádua, Ricardo A. P., et al.
Publicado: (2018)

Nitroreductase-Activatable Morpholino Oligonucleotides for in Vivo Gene Silencing
por: Yamazoe, Sayumi, et al.
Publicado: (2014)

Identification of Enterococcus faecalis enzymes with azoreductases and/or nitroreductase activity
por: Chalansonnet, Valérie, et al.
Publicado: (2017)

Ancient Origins of Allosteric Activation in a Ser/Thr Kinase
por: Hadzipasic, Adelajda, et al.
Publicado: (2020)

From primordial clocks to circadian oscillators
por: Pitsawong, Warintra, et al.
Publicado: (2023)

Identification of a Mycothiol-Dependent Nitroreductase from Mycobacterium tuberculosis
por: Negri, Ana, et al.
Publicado: (2018)

A mammalianized synthetic nitroreductase gene for high-level expression
por: Grohmann, Maik, et al.
Publicado: (2009)

Evolutionary and molecular foundations of multiple contemporary functions of the nitroreductase superfamily
por: Akiva, Eyal, et al.
Publicado: (2017)

Biochemical and structural characterization of Haemophilus influenzae nitroreductase in metabolizing nitroimidazoles
por: Liu, Dake, et al.
Publicado: (2022)

Nitroreductases of bacterial origin in Giardia lamblia: Potential role in detoxification of xenobiotics
por: Müller, Joachim, et al.
Publicado: (2019)

Role of NADPH-insensitive nitroreductase gene to metronidazole resistance of Helicobacter pylori strains
por: Kargar, M., et al.
Publicado: (2010)

Nifurtimox Activation by Trypanosomal Type I Nitroreductases Generates Cytotoxic Nitrile Metabolites
por: Hall, Belinda S., et al.
Publicado: (2011)

Single Amino Acid Switch between a Flavin-Dependent Dehalogenase and Nitroreductase
por: Mukherjee, Arnab, et al.
Publicado: (2015)

Activation of Bicyclic Nitro-drugs by a Novel Nitroreductase (NTR2) in Leishmania
por: Wyllie, Susan, et al.
Publicado: (2016)

Identification of a type I nitroreductase gene in non-virulent Trypanosoma rangeli
por: Montenegro, Marjorie, et al.
Publicado: (2017)

An Activatable Lanthanide Luminescent Probe for Time‐Gated Detection of Nitroreductase in Live Bacteria
por: Brennecke, Benjamin, et al.
Publicado: (2020)

A fast-responsive fluorescent turn-on probe for nitroreductase imaging in living cells
por: Jia, Chengli, et al.
Publicado: (2021)

Nitroreductase-instructed supramolecular assemblies for microbiome regulation to enhance colorectal cancer treatments
por: Chen, Jiali, et al.
Publicado: (2022)

Hemicyanine-Based Near-Infrared Fluorescence Off–On Probes for Imaging Intracellular and In Vivo Nitroreductase Activity
por: Lee, Sun Hyeok, et al.
Publicado: (2023)

Investigating the application of a nitroreductase-expressing transgenic zebrafish line for high-throughput toxicity testing
por: Chlebowski, Anna C., et al.
Publicado: (2017)

Dynamics of human protein kinase Aurora A linked to drug selectivity
por: Pitsawong, Warintra, et al.
Publicado: (2018)

APPLICATION OF 6-NITROCOUMARIN AS A SUBSTRATE FOR THE FLUORESCENT DETECTION OF NITROREDUCTASE ACTIVITY IN Sporothrix schenckii
por: Stopiglia, Cheila Denise Ottonelli, et al.
Publicado: (2013)

Comparative characterisation of two nitroreductases from Giardia lamblia as potential activators of nitro compounds
por: Müller, Joachim, et al.
Publicado: (2015)

Reduction of nitroarenes by magnetically recoverable nitroreductase immobilized on Fe(3)O(4) nanoparticles
por: Zhang, Qikun, et al.
Publicado: (2020)

A nitroreductase responsive and photoactivated fluorescent probe for dual-controlled tumor hypoxia imaging
por: Xu, Jialong, et al.
Publicado: (2022)

Fully biological production of adipic acid analogs from branched catechols
por: Kruyer, Nicholas S., et al.
Publicado: (2020)

A novel nitroreductase-enhanced MRI contrast agent and its potential application in bacterial imaging
por: Liu, Yun, et al.
Publicado: (2018)

Hypoxia imaging in cells and tumor tissues using a highly selective fluorescent nitroreductase probe
por: Yang, Dan, et al.
Publicado: (2017)

Deciphering the biosynthesis of a novel lipid in Mycobacterium tuberculosis expands the known roles of the nitroreductase superfamily
por: Grigg, Jason C., et al.
Publicado: (2023)

How directed evolution reshapes energy landscapes in enzymes to boost catalysis
por: Otten, Renee, et al.
Publicado: (2020)

Structure and substrate specificity determinants of NfnB, a dinitroaniline herbicide–catabolizing nitroreductase from Sphingopyxis sp. strain HMH
por: Kim, Sang-Hoon, et al.
Publicado: (2021)

2-Amino metabolites are key mediators of CB 1954 and SN 23862 bystander effects in nitroreductase GDEPT
por: Helsby, N A, et al.
Publicado: (2004)

Structure of Ddn, the Deazaflavin-Dependent Nitroreductase from Mycobacterium tuberculosis Involved in Bioreductive Activation of PA-824
por: Cellitti, Susan E., et al.
Publicado: (2012)

E. coli NfsA: an alternative nitroreductase for prodrug activation gene therapy in combination with CB1954
por: Vass, S O, et al.
Publicado: (2009)

Structure of Ddn, the Deazaflavin-Dependent Nitroreductase from Mycobacterium tuberculosis Involved in Bioreductive Activation of PA-824
por: Cellitti, Susan E., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_9bm7molhhmdjvscuh7bdb2phnl