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Dual Effects of Alpha-Hydroxy Acids on the Skin

AHAs are organic acids with one hydroxyl group attached to the alpha position of the acid. AHAs including glycolic acid, lactic acid, malic acid, tartaric acid, and citric acid are often used extensively in cosmetic formulations. AHAs have been used as superficial peeling agents as well as to amelio...

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Autores principales: Tang, Sheau-Chung, Yang, Jen-Hung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017965/
https://www.ncbi.nlm.nih.gov/pubmed/29642579
http://dx.doi.org/10.3390/molecules23040863
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author Tang, Sheau-Chung
Yang, Jen-Hung
author_facet Tang, Sheau-Chung
Yang, Jen-Hung
author_sort Tang, Sheau-Chung
collection PubMed
description AHAs are organic acids with one hydroxyl group attached to the alpha position of the acid. AHAs including glycolic acid, lactic acid, malic acid, tartaric acid, and citric acid are often used extensively in cosmetic formulations. AHAs have been used as superficial peeling agents as well as to ameliorate the appearance of keratoses and acne in dermatology. However, caution should be exercised in relation to certain adverse reactions among patients using products with AHAs, including swelling, burning, and pruritus. Whether AHAs enhance or decrease photo damage of the skin remains unclear, compelling us to ask the question, is AHA a friend or a foe of the skin? The aim of this manuscript is to review the various biological effects and mechanisms of AHAs on human keratinocytes and in an animal model. We conclude that whether AHA is a friend or foe of human skin depends on its concentration. These mechanisms of AHAs are currently well understood, aiding the development of novel approaches for the prevention of UV-induced skin damage.
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spelling pubmed-60179652018-11-13 Dual Effects of Alpha-Hydroxy Acids on the Skin Tang, Sheau-Chung Yang, Jen-Hung Molecules Review AHAs are organic acids with one hydroxyl group attached to the alpha position of the acid. AHAs including glycolic acid, lactic acid, malic acid, tartaric acid, and citric acid are often used extensively in cosmetic formulations. AHAs have been used as superficial peeling agents as well as to ameliorate the appearance of keratoses and acne in dermatology. However, caution should be exercised in relation to certain adverse reactions among patients using products with AHAs, including swelling, burning, and pruritus. Whether AHAs enhance or decrease photo damage of the skin remains unclear, compelling us to ask the question, is AHA a friend or a foe of the skin? The aim of this manuscript is to review the various biological effects and mechanisms of AHAs on human keratinocytes and in an animal model. We conclude that whether AHA is a friend or foe of human skin depends on its concentration. These mechanisms of AHAs are currently well understood, aiding the development of novel approaches for the prevention of UV-induced skin damage. MDPI 2018-04-10 /pmc/articles/PMC6017965/ /pubmed/29642579 http://dx.doi.org/10.3390/molecules23040863 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tang, Sheau-Chung
Yang, Jen-Hung
Dual Effects of Alpha-Hydroxy Acids on the Skin
title Dual Effects of Alpha-Hydroxy Acids on the Skin
title_full Dual Effects of Alpha-Hydroxy Acids on the Skin
title_fullStr Dual Effects of Alpha-Hydroxy Acids on the Skin
title_full_unstemmed Dual Effects of Alpha-Hydroxy Acids on the Skin
title_short Dual Effects of Alpha-Hydroxy Acids on the Skin
title_sort dual effects of alpha-hydroxy acids on the skin
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017965/
https://www.ncbi.nlm.nih.gov/pubmed/29642579
http://dx.doi.org/10.3390/molecules23040863
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