Cargando…

Use of an UHPLC-MS/MS Method for Determination of Kuraridin and Characterization of Its Metabolites in Rat Plasma after Oral Administration

Kuraridin is an active natural prenylated flavonoid ingredient originating from the well-known traditional Chinese medicine Sophora flavescens Ait., that possesses various bioactivities, such as antitumor activity, PLC(γ)1 inhibitory activity, glycosidase inhibitory activity, etc. However, there is...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Yi, Chen, Lei, Cai, Wei, Zhao, Lin-lin, Mo, Zhi-xian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017968/ https://www.ncbi.nlm.nih.gov/pubmed/29364156 http://dx.doi.org/10.3390/molecules23020132

Ejemplares similares

UHPLC-MS/MS Determination, Pharmacokinetic, and Bioavailability Study of Taxifolin in Rat Plasma after Oral Administration of its Nanodispersion
por: Yang, Chun-Juan, et al.
Publicado: (2016)

Determination of lesinurad in rat plasma by a UHPLC–MS/MS assay
por: Zhou, Xiao-Yang, et al.
Publicado: (2017)

Quantitative determination of vitamin D metabolites in plasma using UHPLC-MS/MS
por: Ding, Shujing, et al.
Publicado: (2010)

Simultaneous Determination and Pharmacokinetics Study of Six Triterpenes in Rat Plasma by UHPLC-MS/MS after Oral Administration of Sanguisorba officinalis L. Extract
por: Wu, Chengcui, et al.
Publicado: (2018)

Simultaneous Determination of Seven Phenolic Acids in Rat Plasma Using UHPLC-ESI-MS/MS after Oral Administration of Echinacea purpurea Extract
por: Du, Yan, et al.
Publicado: (2017)

Determination and Pharmacokinetic Study of Three Diterpenes in Rat Plasma by UHPLC-ESI-MS/MS after Oral Administration of Rosmarinus officinalis L. Extract
por: Wang, Liqian, et al.
Publicado: (2017)

Rapid Identification of Berberine Metabolites in Rat Plasma by UHPLC-Q-TOF-MS
por: Xu, Peng, et al.
Publicado: (2019)

Identification and Pharmacokinetic Studies on Complanatuside and Its Major Metabolites in Rats by UHPLC-Q-TOF-MS/MS and LC-MS/MS
por: Yao, Yu-Feng, et al.
Publicado: (2018)

Comparative Pharmacokinetic Profiles of Puerarin in Rat Plasma by UHPLC-MS/MS after Oral Administration of Pueraria lobata Extract and Pure Puerarin
por: Zhang, Guozhe, et al.
Publicado: (2020)

Pharmacokinetic Study and Metabolite Identification of CAM106 in Rats by Validated UHPLC-MS/MS
por: Xi, Ruqi, et al.
Publicado: (2023)

Pharmacokinetics and Metabolism Study of Deep-Sea-Derived Butyrolactone I in Rats by UHPLC–MS/MS and UHPLC–Q-TOF-MS
por: Wu, Liang, et al.
Publicado: (2021)

Simultaneous Determination of Eight Alkaloids in Rat Plasma by UHPLC-MS/MS after Oral Administration of Coptis deltoidea C. Y. Cheng et Hsiao and Coptis chinensis Franch
por: Liu, Lu, et al.
Publicado: (2016)

Simultaneous Determination of Five Iridoids of Picrorhiza scrophulariiflora in Rat Plasma Using UHPLC-ESI-MS/MS
por: Wang, Zhibin, et al.
Publicado: (2023)

Identification of the metabolites of isochlorogenic acid A in rats by UHPLC-Q-Exactive Orbitrap MS
por: Gong, Kaiyan, et al.
Publicado: (2020)

Pharmacokinetics and Metabolism Research of Shenkang Injection in Rats Based on UHPLC-MS/MS and UHPLC-Q-Orbitrap HRMS
por: Jiang, Xiaofang, et al.
Publicado: (2020)

A validated UHPLC-MS/MS method for rapid determination of senicapoc in plasma samples
por: Sørensen, Lambert K., et al.
Publicado: (2021)

Simultaneous Determination of Columbianadin and Its Metabolite Columbianetin in Rat Plasma by LC-MS/MS: Application to Pharmacokinetics of Columbianadin after Oral Administration
por: Li, Jin, et al.
Publicado: (2018)

Identification for metabolism profiles and pharmacokinetic studies of tradition Chinese prescription Ji-Ming-San and its major metabolites in rats by UHPLC-Q-TOF-MS/MS and UHPLC-MS/MS
por: Hsieh, Cheng-Yang, et al.
Publicado: (2023)

Development of a Multimatrix UHPLC-MS/MS Method for the Determination of Paracetamol and Its Metabolites in Animal Tissues
por: Pietruk, Konrad, et al.
Publicado: (2021)

Determination of iohexol by capillary blood microsampling and UHPLC-MS/MS
por: Ion, Valentin, et al.
Publicado: (2019)

Determination of Paraquat in Arabidopsis Tissues and Protoplasts by UHPLC-MS/MS
por: Zhao, Mingming, et al.
Publicado: (2023)

LC-MS/MS determination of avanafil and its metabolites in rat plasma and brain: pharmacokinetic study after oral administration and transdermal film application
por: Kammoun, Ahmed K., et al.
Publicado: (2020)

Determination of the Synthetic Cannabinoids JWH-122, JWH-210, UR-144 in Oral Fluid of Consumers by GC-MS and Quantification of Parent Compounds and Metabolites by UHPLC-MS/MS
por: La Maida, Nunzia, et al.
Publicado: (2020)

Metabolite Identification of Isopropoxy Benzene Guanidine in Rat Liver Microsomes by Using UHPLC-Q-TOF-MS/MS
por: Lu, Yixing, et al.
Publicado: (2023)

Secondary Metabolite Profiling of Species of the Genus Usnea by UHPLC-ESI-OT-MS-MS
por: Salgado, Francisco, et al.
Publicado: (2017)

Identification of Metabolites of Eupatorin in Vivo and in Vitro Based on UHPLC-Q-TOF-MS/MS
por: Li, Luya, et al.
Publicado: (2019)

Determination of Anlotinib, a Tyrosine Kinase Inhibitor, in Rat Plasma by UHPLC-MS/MS and Its Application to a Pharmacokinetic Study
por: Wang, Zhe, et al.
Publicado: (2019)

Metabolite Profiling of Meridianin C In Vivo of Rat by UHPLC/Q-TOF MS
por: Zhang, Guozhe, et al.
Publicado: (2021)

Simultaneous Quantification and Pharmacokinetic Study of Five Homologs of Dalbavancin in Rat Plasma Using UHPLC-MS/MS
por: Zhu, Difeng, et al.
Publicado: (2020)

Characterization of URB Series Synthetic Cannabinoids by HRMS and UHPLC–MS/MS
por: Agostini, Marco, et al.
Publicado: (2023)

Simultaneous Determination of Structurally Diverse Compounds in Different Fangchi Species by UHPLC-DAD and UHPLC-ESI-MS/MS
por: Sim, Hee-Jung, et al.
Publicado: (2013)

Simple, sensitive and rapid determination of linifanib (ABT-869), a novel tyrosine kinase inhibitor in rat plasma by UHPLC-MS/MS
por: Iqbal, Muzaffar, et al.
Publicado: (2014)

Simultaneous Determination of Three Compounds in Rat Plasma by UHPLC-QQQ-MS/MS and Its Application to Pharmacokinetics of Banxia Baizhu Tianma Tang
por: Ying, Zheming, et al.
Publicado: (2023)

Identification of metabolites of liquiritin in rats by UHPLC-Q-TOF-MS/MS: metabolic profiling and pathway comparison in vitro and in vivo
por: Zhang, Xia, et al.
Publicado: (2018)

Simultaneous Determination of Seven Active Components in Rat Plasma by UHPLC-MS/MS and Application to a Quantitative Study after Oral Administration of Huang-Lian Jie-Du Decoction in High Fat-Induced Atherosclerosis Rats
por: Jiang, Li, et al.
Publicado: (2019)

Simultaneous Quantification of Pioglitazone and Omarigliptin in Rat Plasma by UHPLC-MS/MS and Its Application to Pharmacokinetic Study after Coadministration of the Two Drugs
por: Wang, Lin, et al.
Publicado: (2021)

UHPLC-MS/MS determination of varietal thiol precursors in Sauvignon Blanc grapes
por: Vanzo, Andreja, et al.
Publicado: (2017)

Dynamic profiling of intact glucosinolates in radish by combining UHPLC-HRMS/MS and UHPLC-QqQ-MS/MS
por: Yan, Chenghuan, et al.
Publicado: (2023)

Development of a UHPLC-MS/MS method for the quantification of ilaprazole enantiomers in rat plasma and its pharmacokinetic application
por: Ou, Fengting, et al.
Publicado: (2020)

Stereoselective pharmacokinetic study of epiprogoitrin and progoitrin in rats with UHPLC–MS/MS method
por: Xu, Yan, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_90gsne0nmgn8fpv0bt3him44gd