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Zn(OAc)(2)-Catalyzing Ring-Opening Polymerization of N-Carboxyanhydrides for the Synthesis of Well-Defined Polypeptides

Despite notable progress, the fabrication of well-defined polypeptides via controlled ring-opening polymerization (ROP) of α-amino acid N-carboxyanhydrides (NCAs) using convenient catalysts under mild conditions in a relatively short polymerization time is still challenging. Herein, an easily obtain...

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Detalles Bibliográficos
Autores principales: Nie, Yanzhao, Zhi, Xinmei, Du, Haifeng, Yang, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017970/
https://www.ncbi.nlm.nih.gov/pubmed/29587473
http://dx.doi.org/10.3390/molecules23040760
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author Nie, Yanzhao
Zhi, Xinmei
Du, Haifeng
Yang, Jing
author_facet Nie, Yanzhao
Zhi, Xinmei
Du, Haifeng
Yang, Jing
author_sort Nie, Yanzhao
collection PubMed
description Despite notable progress, the fabrication of well-defined polypeptides via controlled ring-opening polymerization (ROP) of α-amino acid N-carboxyanhydrides (NCAs) using convenient catalysts under mild conditions in a relatively short polymerization time is still challenging. Herein, an easily obtained catalyst system composed of zinc acetate and aniline was explored to mediate the fast ROP of γ-benzyl-l-glutamate-N-carboxyanhydride (BLG-NCA) monomer, to produce poly(γ-benzyl-l-glutamates) (PBLGs) with controllable molecular weights and narrow dispersity. Considering the excellent cooperative action of zinc acetate and a broad scope of aniline derivatives with different functional groups to control ROP of BLG-NCA, this method may offer a useful platform enabling the rapid generation of end-functionalized PBLG and block copolymers for numerous biomedical applications.
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spelling pubmed-60179702018-11-13 Zn(OAc)(2)-Catalyzing Ring-Opening Polymerization of N-Carboxyanhydrides for the Synthesis of Well-Defined Polypeptides Nie, Yanzhao Zhi, Xinmei Du, Haifeng Yang, Jing Molecules Article Despite notable progress, the fabrication of well-defined polypeptides via controlled ring-opening polymerization (ROP) of α-amino acid N-carboxyanhydrides (NCAs) using convenient catalysts under mild conditions in a relatively short polymerization time is still challenging. Herein, an easily obtained catalyst system composed of zinc acetate and aniline was explored to mediate the fast ROP of γ-benzyl-l-glutamate-N-carboxyanhydride (BLG-NCA) monomer, to produce poly(γ-benzyl-l-glutamates) (PBLGs) with controllable molecular weights and narrow dispersity. Considering the excellent cooperative action of zinc acetate and a broad scope of aniline derivatives with different functional groups to control ROP of BLG-NCA, this method may offer a useful platform enabling the rapid generation of end-functionalized PBLG and block copolymers for numerous biomedical applications. MDPI 2018-03-26 /pmc/articles/PMC6017970/ /pubmed/29587473 http://dx.doi.org/10.3390/molecules23040760 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nie, Yanzhao
Zhi, Xinmei
Du, Haifeng
Yang, Jing
Zn(OAc)(2)-Catalyzing Ring-Opening Polymerization of N-Carboxyanhydrides for the Synthesis of Well-Defined Polypeptides
title Zn(OAc)(2)-Catalyzing Ring-Opening Polymerization of N-Carboxyanhydrides for the Synthesis of Well-Defined Polypeptides
title_full Zn(OAc)(2)-Catalyzing Ring-Opening Polymerization of N-Carboxyanhydrides for the Synthesis of Well-Defined Polypeptides
title_fullStr Zn(OAc)(2)-Catalyzing Ring-Opening Polymerization of N-Carboxyanhydrides for the Synthesis of Well-Defined Polypeptides
title_full_unstemmed Zn(OAc)(2)-Catalyzing Ring-Opening Polymerization of N-Carboxyanhydrides for the Synthesis of Well-Defined Polypeptides
title_short Zn(OAc)(2)-Catalyzing Ring-Opening Polymerization of N-Carboxyanhydrides for the Synthesis of Well-Defined Polypeptides
title_sort zn(oac)(2)-catalyzing ring-opening polymerization of n-carboxyanhydrides for the synthesis of well-defined polypeptides
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017970/
https://www.ncbi.nlm.nih.gov/pubmed/29587473
http://dx.doi.org/10.3390/molecules23040760
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