Perspectives of Immune Suppression in the Tumor Microenvironment Promoting Oral Malignancy

INTRODUCTION: In order to survive, cancers control immune systems and evade immune detection using mediators consisting of immune checkpoint molecules and cellular systems associated with immune suppression. METHODOLOGY: During the development of cancer and chronic infections, the immune checkpoints...

Descripción completa

Detalles Bibliográficos
Autores principales: Kondoh, Nobuo, Mizuno-Kamiya, Masako, Takayama, Eiji, Kawati, Harumi, Umemura, Naoki, Yamazaki, Yutaka, Mitsudo, Kenji, Tohnai, Iwai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Open 2018
Materias:
Dentistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018133/
https://www.ncbi.nlm.nih.gov/pubmed/29988281
http://dx.doi.org/10.2174/1874210601812010455
_version_ 1783334888699592704
author Kondoh, Nobuo
Mizuno-Kamiya, Masako
Takayama, Eiji
Kawati, Harumi
Umemura, Naoki
Yamazaki, Yutaka
Mitsudo, Kenji
Tohnai, Iwai
author_facet Kondoh, Nobuo
Mizuno-Kamiya, Masako
Takayama, Eiji
Kawati, Harumi
Umemura, Naoki
Yamazaki, Yutaka
Mitsudo, Kenji
Tohnai, Iwai
author_sort Kondoh, Nobuo
collection PubMed
description INTRODUCTION: In order to survive, cancers control immune systems and evade immune detection using mediators consisting of immune checkpoint molecules and cellular systems associated with immune suppression. METHODOLOGY: During the development of cancer and chronic infections, the immune checkpoints and cellular components including regulatory T cells, myeloid derived suppressor cells and cancer associated fibroblasts are often enhanced as a mechanism of immune subversion and have therefore become very important therapeutic targets. CONCLUSION: In this review, we will discuss the complexity of immune-suppressive mechanisms in the tumor milieu of cancers, including oral malignancy.
format Online
Article
Text
id pubmed-6018133
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Bentham Open
record_format MEDLINE/PubMed
spelling pubmed-60181332018-07-09 Perspectives of Immune Suppression in the Tumor Microenvironment Promoting Oral Malignancy Kondoh, Nobuo Mizuno-Kamiya, Masako Takayama, Eiji Kawati, Harumi Umemura, Naoki Yamazaki, Yutaka Mitsudo, Kenji Tohnai, Iwai Open Dent J Dentistry INTRODUCTION: In order to survive, cancers control immune systems and evade immune detection using mediators consisting of immune checkpoint molecules and cellular systems associated with immune suppression. METHODOLOGY: During the development of cancer and chronic infections, the immune checkpoints and cellular components including regulatory T cells, myeloid derived suppressor cells and cancer associated fibroblasts are often enhanced as a mechanism of immune subversion and have therefore become very important therapeutic targets. CONCLUSION: In this review, we will discuss the complexity of immune-suppressive mechanisms in the tumor milieu of cancers, including oral malignancy. Bentham Open 2018-06-20 /pmc/articles/PMC6018133/ /pubmed/29988281 http://dx.doi.org/10.2174/1874210601812010455 Text en © 2018 Kondoh et al. https://creativecommons.org/licenses/by/4.0/legalcode This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: (https://creativecommons.org/licenses/by/4.0/legalcode). This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Dentistry
Kondoh, Nobuo
Mizuno-Kamiya, Masako
Takayama, Eiji
Kawati, Harumi
Umemura, Naoki
Yamazaki, Yutaka
Mitsudo, Kenji
Tohnai, Iwai
Perspectives of Immune Suppression in the Tumor Microenvironment Promoting Oral Malignancy
title Perspectives of Immune Suppression in the Tumor Microenvironment Promoting Oral Malignancy
title_full Perspectives of Immune Suppression in the Tumor Microenvironment Promoting Oral Malignancy
title_fullStr Perspectives of Immune Suppression in the Tumor Microenvironment Promoting Oral Malignancy
title_full_unstemmed Perspectives of Immune Suppression in the Tumor Microenvironment Promoting Oral Malignancy
title_short Perspectives of Immune Suppression in the Tumor Microenvironment Promoting Oral Malignancy
title_sort perspectives of immune suppression in the tumor microenvironment promoting oral malignancy
topic Dentistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018133/
https://www.ncbi.nlm.nih.gov/pubmed/29988281
http://dx.doi.org/10.2174/1874210601812010455
work_keys_str_mv AT kondohnobuo perspectivesofimmunesuppressioninthetumormicroenvironmentpromotingoralmalignancy
AT mizunokamiyamasako perspectivesofimmunesuppressioninthetumormicroenvironmentpromotingoralmalignancy
AT takayamaeiji perspectivesofimmunesuppressioninthetumormicroenvironmentpromotingoralmalignancy
AT kawatiharumi perspectivesofimmunesuppressioninthetumormicroenvironmentpromotingoralmalignancy
AT umemuranaoki perspectivesofimmunesuppressioninthetumormicroenvironmentpromotingoralmalignancy
AT yamazakiyutaka perspectivesofimmunesuppressioninthetumormicroenvironmentpromotingoralmalignancy
AT mitsudokenji perspectivesofimmunesuppressioninthetumormicroenvironmentpromotingoralmalignancy
AT tohnaiiwai perspectivesofimmunesuppressioninthetumormicroenvironmentpromotingoralmalignancy

Ejemplares similares