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Effects of Uric Acid on the Alterations of White Matter Connectivity in Patients with Major Depression
OBJECTIVE: Uric acid is a non-enzymatic antioxidant associated with depression. Despite its known protective role in other brain disorders, little is known about its influence on the structural characteristics of brains of patients with major depressive disorder (MDD). This study explored the associ...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Neuropsychiatric Association
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018146/ https://www.ncbi.nlm.nih.gov/pubmed/29865782 http://dx.doi.org/10.30773/pi.2017.12.17 |
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author | Sohn, Hoyoung Kwon, Min-Soo Lee, Sun-Woo Oh, Jongsoo Kim, Min-Kyoung Lee, Sang-Hyuk Lee, Kang Soo Kim, Borah |
author_facet | Sohn, Hoyoung Kwon, Min-Soo Lee, Sun-Woo Oh, Jongsoo Kim, Min-Kyoung Lee, Sang-Hyuk Lee, Kang Soo Kim, Borah |
author_sort | Sohn, Hoyoung |
collection | PubMed |
description | OBJECTIVE: Uric acid is a non-enzymatic antioxidant associated with depression. Despite its known protective role in other brain disorders, little is known about its influence on the structural characteristics of brains of patients with major depressive disorder (MDD). This study explored the association between uric acid and characteristics of white matter (WM) in patients with MDD. METHODS: A total of 32 patients with MDD and 23 healthy controls (HCs) were examined. All participants were scored based on the Beck Depression Inventory and Beck Anxiety Inventory at baseline. All patients were also rated with the Hamilton Depression Rating Scale. We collected blood samples from all participants immediately after their enrollment and before the initiation of antidepressants in case of patients. Tract-based spatial statistics were used for all imaging analyses. RESULTS: Lower fractional anisotropy (FA) and higher radial diffusivity (RD) values were found in the MDD group than in the HC group. Voxelwise correlation analysis revealed that the serum uric acid levels positively correlated with the FA and negatively with the RD in WM regions that previously showed significant group differences in the MDD group. The correlated areas were located in the left anterior corona radiata, left frontal lobe WM, and left anterior cingulate cortex WM. CONCLUSION: The present study suggests a significant association between altered WM connectivity and serum uric acid levels in patients with MDD, possibly through demyelination. |
format | Online Article Text |
id | pubmed-6018146 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Korean Neuropsychiatric Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-60181462018-06-29 Effects of Uric Acid on the Alterations of White Matter Connectivity in Patients with Major Depression Sohn, Hoyoung Kwon, Min-Soo Lee, Sun-Woo Oh, Jongsoo Kim, Min-Kyoung Lee, Sang-Hyuk Lee, Kang Soo Kim, Borah Psychiatry Investig Original Article OBJECTIVE: Uric acid is a non-enzymatic antioxidant associated with depression. Despite its known protective role in other brain disorders, little is known about its influence on the structural characteristics of brains of patients with major depressive disorder (MDD). This study explored the association between uric acid and characteristics of white matter (WM) in patients with MDD. METHODS: A total of 32 patients with MDD and 23 healthy controls (HCs) were examined. All participants were scored based on the Beck Depression Inventory and Beck Anxiety Inventory at baseline. All patients were also rated with the Hamilton Depression Rating Scale. We collected blood samples from all participants immediately after their enrollment and before the initiation of antidepressants in case of patients. Tract-based spatial statistics were used for all imaging analyses. RESULTS: Lower fractional anisotropy (FA) and higher radial diffusivity (RD) values were found in the MDD group than in the HC group. Voxelwise correlation analysis revealed that the serum uric acid levels positively correlated with the FA and negatively with the RD in WM regions that previously showed significant group differences in the MDD group. The correlated areas were located in the left anterior corona radiata, left frontal lobe WM, and left anterior cingulate cortex WM. CONCLUSION: The present study suggests a significant association between altered WM connectivity and serum uric acid levels in patients with MDD, possibly through demyelination. Korean Neuropsychiatric Association 2018-06 2018-06-07 /pmc/articles/PMC6018146/ /pubmed/29865782 http://dx.doi.org/10.30773/pi.2017.12.17 Text en Copyright © 2018 Korean Neuropsychiatric Association This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Sohn, Hoyoung Kwon, Min-Soo Lee, Sun-Woo Oh, Jongsoo Kim, Min-Kyoung Lee, Sang-Hyuk Lee, Kang Soo Kim, Borah Effects of Uric Acid on the Alterations of White Matter Connectivity in Patients with Major Depression |
title | Effects of Uric Acid on the Alterations of White Matter Connectivity in Patients with Major Depression |
title_full | Effects of Uric Acid on the Alterations of White Matter Connectivity in Patients with Major Depression |
title_fullStr | Effects of Uric Acid on the Alterations of White Matter Connectivity in Patients with Major Depression |
title_full_unstemmed | Effects of Uric Acid on the Alterations of White Matter Connectivity in Patients with Major Depression |
title_short | Effects of Uric Acid on the Alterations of White Matter Connectivity in Patients with Major Depression |
title_sort | effects of uric acid on the alterations of white matter connectivity in patients with major depression |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018146/ https://www.ncbi.nlm.nih.gov/pubmed/29865782 http://dx.doi.org/10.30773/pi.2017.12.17 |
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