Simultaneous and stoichiometric purification of hundreds of oligonucleotides

Purification of oligonucleotides has traditionally relied on mobility-based separation methods. However, these are imperfect, biased, and difficult to scale high multiplex. Here, we present a method for simultaneous purification of many oligonucleotides that also normalizes concentrations. The metho...

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Detalles Bibliográficos
Autores principales: Pinto, Alessandro, Chen, Sherry X., Zhang, David Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018234/
https://www.ncbi.nlm.nih.gov/pubmed/29941961
http://dx.doi.org/10.1038/s41467-018-04870-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018234/
https://www.ncbi.nlm.nih.gov/pubmed/29941961
http://dx.doi.org/10.1038/s41467-018-04870-w

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