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Vitamin C in Cancer: A Metabolomics Perspective
There is an ongoing interest in cellular antioxidants and oxidants as well as cellular mechanisms underlying their effects. Several reports suggest that vitamin C (L-ascorbic acid) functions as a pro-oxidant with selective toxicity against specific types of tumor cells. In addition, reduced glutathi...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018397/ https://www.ncbi.nlm.nih.gov/pubmed/29971019 http://dx.doi.org/10.3389/fphys.2018.00762 |
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author | Park, Seyeon Ahn, Seunghyun Shin, Yujeong Yang, Yoonjung Yeom, Chang H. |
author_facet | Park, Seyeon Ahn, Seunghyun Shin, Yujeong Yang, Yoonjung Yeom, Chang H. |
author_sort | Park, Seyeon |
collection | PubMed |
description | There is an ongoing interest in cellular antioxidants and oxidants as well as cellular mechanisms underlying their effects. Several reports suggest that vitamin C (L-ascorbic acid) functions as a pro-oxidant with selective toxicity against specific types of tumor cells. In addition, reduced glutathione plays an emerging role in reducing oxidative stress due to xenobiotic toxins such as metals and oxidants associated with diseases such as cancer, cardiovascular disease, and stroke. High-dose intravenous vitamin C and intravenous glutathione have been used as complementary, alternative, and adjuvant medicines. Here, we review the molecular mechanisms underlying the regulation of oxidation/reduction systems, focusing on the altered metabolomics profile in cancer cells following treatment with pharmacological vitamin C. This review focuses on the role of vitamin C in energy metabolism in terms of adenosine triphosphate, cysteine, and reduced glutathione levels, affecting cancer cell death. |
format | Online Article Text |
id | pubmed-6018397 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-60183972018-07-03 Vitamin C in Cancer: A Metabolomics Perspective Park, Seyeon Ahn, Seunghyun Shin, Yujeong Yang, Yoonjung Yeom, Chang H. Front Physiol Physiology There is an ongoing interest in cellular antioxidants and oxidants as well as cellular mechanisms underlying their effects. Several reports suggest that vitamin C (L-ascorbic acid) functions as a pro-oxidant with selective toxicity against specific types of tumor cells. In addition, reduced glutathione plays an emerging role in reducing oxidative stress due to xenobiotic toxins such as metals and oxidants associated with diseases such as cancer, cardiovascular disease, and stroke. High-dose intravenous vitamin C and intravenous glutathione have been used as complementary, alternative, and adjuvant medicines. Here, we review the molecular mechanisms underlying the regulation of oxidation/reduction systems, focusing on the altered metabolomics profile in cancer cells following treatment with pharmacological vitamin C. This review focuses on the role of vitamin C in energy metabolism in terms of adenosine triphosphate, cysteine, and reduced glutathione levels, affecting cancer cell death. Frontiers Media S.A. 2018-06-19 /pmc/articles/PMC6018397/ /pubmed/29971019 http://dx.doi.org/10.3389/fphys.2018.00762 Text en Copyright © 2018 Park, Ahn, Shin, Yang and Yeom. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Park, Seyeon Ahn, Seunghyun Shin, Yujeong Yang, Yoonjung Yeom, Chang H. Vitamin C in Cancer: A Metabolomics Perspective |
title | Vitamin C in Cancer: A Metabolomics Perspective |
title_full | Vitamin C in Cancer: A Metabolomics Perspective |
title_fullStr | Vitamin C in Cancer: A Metabolomics Perspective |
title_full_unstemmed | Vitamin C in Cancer: A Metabolomics Perspective |
title_short | Vitamin C in Cancer: A Metabolomics Perspective |
title_sort | vitamin c in cancer: a metabolomics perspective |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018397/ https://www.ncbi.nlm.nih.gov/pubmed/29971019 http://dx.doi.org/10.3389/fphys.2018.00762 |
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