2-[2-(4-(trifluoromethyl)phenylamino)thiazol-4-yl]acetic acid (Activator-3) is a potent activator of AMPK

AMPK is considered as a potential high value target for metabolic disorders. Here, we present the molecular modeling, in vitro and in vivo characterization of Activator-3, 2-[2-(4-(trifluoromethyl)phenylamino)thiazol-4-yl]acetic acid, an AMP mimetic and a potent pan-AMPK activator. Activator-3 and A...

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Detalles Bibliográficos
Autores principales: Bung, Navneet, Surepalli, Sobhitha, Seshadri, Sriram, Patel, Sweta, Peddasomayajula, Saranya, Kummari, Lalith Kumar, Kumar, Sireesh T., Babu, Phanithi Prakash, Parsa, Kishore V. L., Poondra, Rajamohan Reddy, Bulusu, Gopalakrishnan, Misra, Parimal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018554/
https://www.ncbi.nlm.nih.gov/pubmed/29942003
http://dx.doi.org/10.1038/s41598-018-27974-1

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