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Phyllostictine A: total synthesis, structural verification and determination of substructure responsible for plant growth inhibition

The first total synthesis of phyllostictine A (PA) is reported, which confirms the structure of this fungal metabolite and its (6S,7R,8S)-stereochemistry. Both synthetic PA and an analogue containing the 5-methylene-1,5-dihydro-2H-pyrrol-2-one nucleus exhibit μM inhibitory activity in root growth as...

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Detalles Bibliográficos
Autores principales:	Riemer, Martin, Uzunova, Veselina V., Riemer, Nastja, Clarkson, Guy J., Pereira, Nicole, Napier, Richard, Shipman, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2018
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018569/ https://www.ncbi.nlm.nih.gov/pubmed/29897060 http://dx.doi.org/10.1039/c8cc03349h

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