Dissecting the mammary gland one cell at a time

Dissecting cellular differentiation hierarchies in the mammary gland is a prerequisite for understanding both normal development and malignant transformation during tumorigenesis and tumor cell-of-origin. To achieve these goals, several recent papers utilized single cell RNA-seq and lineage tracing...

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Detalles Bibliográficos
Autores principales: Cristea, Simona, Polyak, Kornelia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018702/
https://www.ncbi.nlm.nih.gov/pubmed/29946144
http://dx.doi.org/10.1038/s41467-018-04905-2
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author Cristea, Simona
Polyak, Kornelia
author_facet Cristea, Simona
Polyak, Kornelia
author_sort Cristea, Simona
collection PubMed
description Dissecting cellular differentiation hierarchies in the mammary gland is a prerequisite for understanding both normal development and malignant transformation during tumorigenesis and tumor cell-of-origin. To achieve these goals, several recent papers utilized single cell RNA-seq and lineage tracing to improve our understanding of the composition of the mammary epithelium at different developmental stages.
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spelling pubmed-60187022018-06-27 Dissecting the mammary gland one cell at a time Cristea, Simona Polyak, Kornelia Nat Commun Comment Dissecting cellular differentiation hierarchies in the mammary gland is a prerequisite for understanding both normal development and malignant transformation during tumorigenesis and tumor cell-of-origin. To achieve these goals, several recent papers utilized single cell RNA-seq and lineage tracing to improve our understanding of the composition of the mammary epithelium at different developmental stages. Nature Publishing Group UK 2018-06-26 /pmc/articles/PMC6018702/ /pubmed/29946144 http://dx.doi.org/10.1038/s41467-018-04905-2 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Comment
Cristea, Simona
Polyak, Kornelia
Dissecting the mammary gland one cell at a time
title Dissecting the mammary gland one cell at a time
title_full Dissecting the mammary gland one cell at a time
title_fullStr Dissecting the mammary gland one cell at a time
title_full_unstemmed Dissecting the mammary gland one cell at a time
title_short Dissecting the mammary gland one cell at a time
title_sort dissecting the mammary gland one cell at a time
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018702/
https://www.ncbi.nlm.nih.gov/pubmed/29946144
http://dx.doi.org/10.1038/s41467-018-04905-2
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