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Prevalence of degenerative changes and overlap with spondyloarthritis-associated lesions in the spine of patients from the DESIR cohort

OBJECTIVES: To describe the prevalence of degenerative changes on MRI and conventional radiographs of the spine in a young population with suspicion of axial spondyloarthritis (axSpA) and assess whether it is possible to discriminate between degenerative changes and lesions associated with axSpA. ME...

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Autores principales: de Bruin, Freek, Treyvaud, Marco O, Feydy, Antoine, de Hooge, Manouk, Pialat, Jean-Baptiste, Dougados, Maxime, Gossec, Laure, Bloem, Johan L, van der Heijde, Désirée, Reijnierse, Monique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018874/
https://www.ncbi.nlm.nih.gov/pubmed/29955382
http://dx.doi.org/10.1136/rmdopen-2018-000657
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author de Bruin, Freek
Treyvaud, Marco O
Feydy, Antoine
de Hooge, Manouk
Pialat, Jean-Baptiste
Dougados, Maxime
Gossec, Laure
Bloem, Johan L
van der Heijde, Désirée
Reijnierse, Monique
author_facet de Bruin, Freek
Treyvaud, Marco O
Feydy, Antoine
de Hooge, Manouk
Pialat, Jean-Baptiste
Dougados, Maxime
Gossec, Laure
Bloem, Johan L
van der Heijde, Désirée
Reijnierse, Monique
author_sort de Bruin, Freek
collection PubMed
description OBJECTIVES: To describe the prevalence of degenerative changes on MRI and conventional radiographs of the spine in a young population with suspicion of axial spondyloarthritis (axSpA) and assess whether it is possible to discriminate between degenerative changes and lesions associated with axSpA. METHODS: Whole spine MRI and cervical and lumbar radiographs of patients ≥18 years with chronic back pain (≥3 months, ≤3 years, onset <50 years) were assessed for degeneration by two readers, and for SpA lesions by two other readers, all blinded for clinical information and results of the other readers. Degenerative scores were adjudicated in case of disagreement (by a third reader). Patients fulfilling and not fulfilling the Assessment of SpondyloArthritis international Society axSpA criteria were compared for prevalence of degenerative lesions. Scores for degenerative and SpA lesions were compared, and overlap was defined as the presence of both types of lesions in a single vertebral unit (VU). RESULTS: In 456/648 (70.4%) patients (46.8% men, mean age 33.6), degenerative lesions were found with similar percentages in patients with no axSpA and with axSpA (72.4% and 69.2%, p=0.45). Modic changes were found more often in patients with no axSpA (29/239, 12.1%) versus patients with axSpA (19/409, 4.6%, p=0.01). Other lesions were evenly distributed. Overlap was minimal in 19 patients (3.0%) and 32/14 674 (0.2%) VUs for SpA reader 1 and in 23 patients (3.6%) and 34/14 674 VUs (0.2%) for SpA reader 2. CONCLUSION: The prevalence of degeneration is high in an early inflammatory back pain cohort. Discrimination between degeneration and axSpA lesions is very well possible with little overlap between degenerative and axSpA readings.
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spelling pubmed-60188742018-06-28 Prevalence of degenerative changes and overlap with spondyloarthritis-associated lesions in the spine of patients from the DESIR cohort de Bruin, Freek Treyvaud, Marco O Feydy, Antoine de Hooge, Manouk Pialat, Jean-Baptiste Dougados, Maxime Gossec, Laure Bloem, Johan L van der Heijde, Désirée Reijnierse, Monique RMD Open Spondyloarthritis OBJECTIVES: To describe the prevalence of degenerative changes on MRI and conventional radiographs of the spine in a young population with suspicion of axial spondyloarthritis (axSpA) and assess whether it is possible to discriminate between degenerative changes and lesions associated with axSpA. METHODS: Whole spine MRI and cervical and lumbar radiographs of patients ≥18 years with chronic back pain (≥3 months, ≤3 years, onset <50 years) were assessed for degeneration by two readers, and for SpA lesions by two other readers, all blinded for clinical information and results of the other readers. Degenerative scores were adjudicated in case of disagreement (by a third reader). Patients fulfilling and not fulfilling the Assessment of SpondyloArthritis international Society axSpA criteria were compared for prevalence of degenerative lesions. Scores for degenerative and SpA lesions were compared, and overlap was defined as the presence of both types of lesions in a single vertebral unit (VU). RESULTS: In 456/648 (70.4%) patients (46.8% men, mean age 33.6), degenerative lesions were found with similar percentages in patients with no axSpA and with axSpA (72.4% and 69.2%, p=0.45). Modic changes were found more often in patients with no axSpA (29/239, 12.1%) versus patients with axSpA (19/409, 4.6%, p=0.01). Other lesions were evenly distributed. Overlap was minimal in 19 patients (3.0%) and 32/14 674 (0.2%) VUs for SpA reader 1 and in 23 patients (3.6%) and 34/14 674 VUs (0.2%) for SpA reader 2. CONCLUSION: The prevalence of degeneration is high in an early inflammatory back pain cohort. Discrimination between degeneration and axSpA lesions is very well possible with little overlap between degenerative and axSpA readings. BMJ Publishing Group 2018-06-06 /pmc/articles/PMC6018874/ /pubmed/29955382 http://dx.doi.org/10.1136/rmdopen-2018-000657 Text en © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Spondyloarthritis
de Bruin, Freek
Treyvaud, Marco O
Feydy, Antoine
de Hooge, Manouk
Pialat, Jean-Baptiste
Dougados, Maxime
Gossec, Laure
Bloem, Johan L
van der Heijde, Désirée
Reijnierse, Monique
Prevalence of degenerative changes and overlap with spondyloarthritis-associated lesions in the spine of patients from the DESIR cohort
title Prevalence of degenerative changes and overlap with spondyloarthritis-associated lesions in the spine of patients from the DESIR cohort
title_full Prevalence of degenerative changes and overlap with spondyloarthritis-associated lesions in the spine of patients from the DESIR cohort
title_fullStr Prevalence of degenerative changes and overlap with spondyloarthritis-associated lesions in the spine of patients from the DESIR cohort
title_full_unstemmed Prevalence of degenerative changes and overlap with spondyloarthritis-associated lesions in the spine of patients from the DESIR cohort
title_short Prevalence of degenerative changes and overlap with spondyloarthritis-associated lesions in the spine of patients from the DESIR cohort
title_sort prevalence of degenerative changes and overlap with spondyloarthritis-associated lesions in the spine of patients from the desir cohort
topic Spondyloarthritis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018874/
https://www.ncbi.nlm.nih.gov/pubmed/29955382
http://dx.doi.org/10.1136/rmdopen-2018-000657
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