BK virus pneumonia following stem cell transplantation against diffuse large B‐cell lymphoma

The patient, a 70‐year‐old woman with diffuse large B‐cell lymphoma (DLBCL), developed haemorrhagic cystitis associated with the BK virus (BKV) and adenovirus type 11. Moreover, chest computed tomography showed ground‐glass opacity (GGO) in the bilateral upper lobe, and we performed bronchoalveolar...

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Autores principales: Yoshimura, Akihiro, Tsuji, Taisuke, Kawaji, Yuka, Hirakawa, Yoshiko, Uchiyama, Hitoji, Hiraoka, Noriya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2018
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018942/
https://www.ncbi.nlm.nih.gov/pubmed/29983984
http://dx.doi.org/10.1002/rcr2.348
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author Yoshimura, Akihiro
Tsuji, Taisuke
Kawaji, Yuka
Hirakawa, Yoshiko
Uchiyama, Hitoji
Hiraoka, Noriya
author_facet Yoshimura, Akihiro
Tsuji, Taisuke
Kawaji, Yuka
Hirakawa, Yoshiko
Uchiyama, Hitoji
Hiraoka, Noriya
author_sort Yoshimura, Akihiro
collection PubMed
description The patient, a 70‐year‐old woman with diffuse large B‐cell lymphoma (DLBCL), developed haemorrhagic cystitis associated with the BK virus (BKV) and adenovirus type 11. Moreover, chest computed tomography showed ground‐glass opacity (GGO) in the bilateral upper lobe, and we performed bronchoalveolar lavage (BAL). The BKV DNA load was elevated not only in blood but also in BAL fluid (BALF), leading to the diagnosis of BKV pneumonia. After administering cidofovir, the respiratory symptoms and GGO abated. Therefore, detection of BKV DNA in BALF is useful for diagnosing BKV pneumonia. The patient with DLBCL developed BKV pneumonia. We performed BAL, and BKV DNA load was elevated on BALF. The detection of BKV DNA in BALF is useful for diagnosing BKV pneumonia.
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spelling pubmed-60189422018-07-06 BK virus pneumonia following stem cell transplantation against diffuse large B‐cell lymphoma Yoshimura, Akihiro Tsuji, Taisuke Kawaji, Yuka Hirakawa, Yoshiko Uchiyama, Hitoji Hiraoka, Noriya Respirol Case Rep Case Reports The patient, a 70‐year‐old woman with diffuse large B‐cell lymphoma (DLBCL), developed haemorrhagic cystitis associated with the BK virus (BKV) and adenovirus type 11. Moreover, chest computed tomography showed ground‐glass opacity (GGO) in the bilateral upper lobe, and we performed bronchoalveolar lavage (BAL). The BKV DNA load was elevated not only in blood but also in BAL fluid (BALF), leading to the diagnosis of BKV pneumonia. After administering cidofovir, the respiratory symptoms and GGO abated. Therefore, detection of BKV DNA in BALF is useful for diagnosing BKV pneumonia. The patient with DLBCL developed BKV pneumonia. We performed BAL, and BKV DNA load was elevated on BALF. The detection of BKV DNA in BALF is useful for diagnosing BKV pneumonia. John Wiley & Sons, Ltd 2018-06-26 /pmc/articles/PMC6018942/ /pubmed/29983984 http://dx.doi.org/10.1002/rcr2.348 Text en © 2018 The Authors. Respirology Case Reports published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Yoshimura, Akihiro
Tsuji, Taisuke
Kawaji, Yuka
Hirakawa, Yoshiko
Uchiyama, Hitoji
Hiraoka, Noriya
BK virus pneumonia following stem cell transplantation against diffuse large B‐cell lymphoma
title BK virus pneumonia following stem cell transplantation against diffuse large B‐cell lymphoma
title_full BK virus pneumonia following stem cell transplantation against diffuse large B‐cell lymphoma
title_fullStr BK virus pneumonia following stem cell transplantation against diffuse large B‐cell lymphoma
title_full_unstemmed BK virus pneumonia following stem cell transplantation against diffuse large B‐cell lymphoma
title_short BK virus pneumonia following stem cell transplantation against diffuse large B‐cell lymphoma
title_sort bk virus pneumonia following stem cell transplantation against diffuse large b‐cell lymphoma
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018942/
https://www.ncbi.nlm.nih.gov/pubmed/29983984
http://dx.doi.org/10.1002/rcr2.348
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