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Up-regulation of cholesterol 24-hydroxylase following hypoxia-ischemia in neonatal mouse brain

BACKGROUND: Maintenance of cholesterol homeostasis is crucial for brain development. Brain cholesterol relies on de novo synthesis and is cleared primarily by conversion to 24S-hydroxycholesterol (24S-HC) with brain-specific cholesterol 24-hydroxylase (CYP46A1). We aimed to investigate the impact of...

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Detalles Bibliográficos
Autores principales:	Lu, Fuxin, Zhu, Jun, Guo, Selena, Wong, Brandon J, Chehab, Farid F., Ferriero, Donna M., Jiang, Xiangning
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019156/ https://www.ncbi.nlm.nih.gov/pubmed/29718007 http://dx.doi.org/10.1038/pr.2018.49

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