经支气管镜针吸活检联合现场细胞学对肺癌诊断的临床价值

BACKGROUND AND OBJECTIVE: There have been several studys about transbronchial needle aspiration (TBNA) combined with rapid on-site evaluation (ROSE) so far at home and abroad, yet few studys were especially for patients with lung cancer. The aim of our study is to investigate the effect of TBNA combined with ROSE in the diagnosis of lung cancer. METHODS: The data of the patients from December 2012 to December 2013, who were performed with TBNA and ultimately diagnosed with lung cancer in the People's Hospital of Binzhou City, were retrospectively analyzed. The patients were divided into two groups, ROSE group (rapid on-site evaluation group) and no-ROSE group (the group without rapid on-site evaluation). Among these patients, 37 patients were in the ROSE group and 32 patients were in the no-ROSE group. The result of ROSE and HE stain, the diagnostic yields and needle passes of each lymph node, the complication and cytology diagnostic cost of TBNA with ROSE and without ROSE were compared. RESULTS: The coherence of ROSE and HE stain was 94.1% (32/34). The diagnostic yields of TBNA were 91.9% (34/37) and 78.1% (25/32) in ROSE group and no-ROSE group respectively, no significant differences were found. But the median number of needle passes of each lymph node and the percentage of the complication in ROSE group and no-ROSE group was significantly lower (t=29.5, P < 0.05 and χ(2)=4.4, P < 0.05, respectively). The cytopathological diagnostic cost of ROSE group was significantly lower compared with no-Rose group (t=10.9, P < 0.05). CONCLUSION: TBNA combined with ROSE has good concordance with HE stain in the diagnosis of lung cancer, and could reduce the needle passes, cytopathological diagnostic cost and complication, worthy of popularized.