肺癌低氧微环境与化疗耐药相关性研究进展

Lung cancer is one of the malignant tumors with highest incidence recently in our country. Tumor hypoxia phenomenon was first discovered in lung cancer. It plays important roles in tumor cell drug-resistance, apoptosis, invasion and metastasis, angiogenesis. Chemotherapy-resistant is one of the core reasons of treatment failure and disease progress, and many works on the study of chemotherapy-resistant have been done. This article reviewed the research progress of those mechanisms by which lung cancer hypoxia microenvironment could induce chemotherapy-resistance.