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The association of neutrophil to lymphocyte ratio, mean platelet volume, and platelet distribution width with diabetic retinopathy and nephropathy: a meta-analysis

The aim of the present study was to investigate the correlation of neutrophil to lymphocyte ratio (NLR), mean platelet volume (MPV), and platelet distribution width (PDW) with diabetic nephropathy (DN) and diabetic retinopathy (DR). We searched for eligible studies from PubMed, Embase, Web of Scienc...

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Autores principales: Liu, Juxiang, Liu, Xingguang, Li, Youpeng, Quan, Jinxing, Wei, Suhong, An, Siqin, Yang, Ruifei, Liu, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019380/
https://www.ncbi.nlm.nih.gov/pubmed/29581246
http://dx.doi.org/10.1042/BSR20180172
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author Liu, Juxiang
Liu, Xingguang
Li, Youpeng
Quan, Jinxing
Wei, Suhong
An, Siqin
Yang, Ruifei
Liu, Jing
author_facet Liu, Juxiang
Liu, Xingguang
Li, Youpeng
Quan, Jinxing
Wei, Suhong
An, Siqin
Yang, Ruifei
Liu, Jing
author_sort Liu, Juxiang
collection PubMed
description The aim of the present study was to investigate the correlation of neutrophil to lymphocyte ratio (NLR), mean platelet volume (MPV), and platelet distribution width (PDW) with diabetic nephropathy (DN) and diabetic retinopathy (DR). We searched for eligible studies from PubMed, Embase, Web of Science, and CNKI up to 1 December 2017. Standardized mean difference (SMD) was calculated with a confidence interval (CI) of 95%. A total of 48 studies were included in our meta-analysis. Compared with patients with type Ⅱ diabetes mellitus (T2DM) and without DR, NLR, MPV, and PDW were higher in patients with DR (SMD = 0.77; 95% CI: 0.49–1.05; P<0.001; SMD = 0.68; 95% CI: 0.36–0.99; P<0.001; SMD = 0.52; 95% CI: 0.28–0.76; P<0.01). Compared with patients with T2DM and without DN, NLR, MPV, and PDW were higher in patients with DN (SMD = 0.63; 95% CI: 0.43–0.83; P<0.001; SMD = 0.81; 95% CI: 0.36–1.25; P<0.001; SMD = 0.70; 95% CI: 0.50–0.90; P<0.001). We also found that MPV was strongly associated with the severity of DR, and NLR was closely related to the degree of DN. Our findings indicated that NLR, MPV, and PDW could be recommended as inexpensive diagnostic biomarkers for DN and DR. However, considering several limitations in the present study, further high-quality clinical studies should be performed to investigate the relationship of NLR, MPV, and PDW to DN and DR.
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spelling pubmed-60193802018-07-05 The association of neutrophil to lymphocyte ratio, mean platelet volume, and platelet distribution width with diabetic retinopathy and nephropathy: a meta-analysis Liu, Juxiang Liu, Xingguang Li, Youpeng Quan, Jinxing Wei, Suhong An, Siqin Yang, Ruifei Liu, Jing Biosci Rep Research Articles The aim of the present study was to investigate the correlation of neutrophil to lymphocyte ratio (NLR), mean platelet volume (MPV), and platelet distribution width (PDW) with diabetic nephropathy (DN) and diabetic retinopathy (DR). We searched for eligible studies from PubMed, Embase, Web of Science, and CNKI up to 1 December 2017. Standardized mean difference (SMD) was calculated with a confidence interval (CI) of 95%. A total of 48 studies were included in our meta-analysis. Compared with patients with type Ⅱ diabetes mellitus (T2DM) and without DR, NLR, MPV, and PDW were higher in patients with DR (SMD = 0.77; 95% CI: 0.49–1.05; P<0.001; SMD = 0.68; 95% CI: 0.36–0.99; P<0.001; SMD = 0.52; 95% CI: 0.28–0.76; P<0.01). Compared with patients with T2DM and without DN, NLR, MPV, and PDW were higher in patients with DN (SMD = 0.63; 95% CI: 0.43–0.83; P<0.001; SMD = 0.81; 95% CI: 0.36–1.25; P<0.001; SMD = 0.70; 95% CI: 0.50–0.90; P<0.001). We also found that MPV was strongly associated with the severity of DR, and NLR was closely related to the degree of DN. Our findings indicated that NLR, MPV, and PDW could be recommended as inexpensive diagnostic biomarkers for DN and DR. However, considering several limitations in the present study, further high-quality clinical studies should be performed to investigate the relationship of NLR, MPV, and PDW to DN and DR. Portland Press Ltd. 2018-06-27 /pmc/articles/PMC6019380/ /pubmed/29581246 http://dx.doi.org/10.1042/BSR20180172 Text en © 2018 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Articles
Liu, Juxiang
Liu, Xingguang
Li, Youpeng
Quan, Jinxing
Wei, Suhong
An, Siqin
Yang, Ruifei
Liu, Jing
The association of neutrophil to lymphocyte ratio, mean platelet volume, and platelet distribution width with diabetic retinopathy and nephropathy: a meta-analysis
title The association of neutrophil to lymphocyte ratio, mean platelet volume, and platelet distribution width with diabetic retinopathy and nephropathy: a meta-analysis
title_full The association of neutrophil to lymphocyte ratio, mean platelet volume, and platelet distribution width with diabetic retinopathy and nephropathy: a meta-analysis
title_fullStr The association of neutrophil to lymphocyte ratio, mean platelet volume, and platelet distribution width with diabetic retinopathy and nephropathy: a meta-analysis
title_full_unstemmed The association of neutrophil to lymphocyte ratio, mean platelet volume, and platelet distribution width with diabetic retinopathy and nephropathy: a meta-analysis
title_short The association of neutrophil to lymphocyte ratio, mean platelet volume, and platelet distribution width with diabetic retinopathy and nephropathy: a meta-analysis
title_sort association of neutrophil to lymphocyte ratio, mean platelet volume, and platelet distribution width with diabetic retinopathy and nephropathy: a meta-analysis
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019380/
https://www.ncbi.nlm.nih.gov/pubmed/29581246
http://dx.doi.org/10.1042/BSR20180172
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