Cargando…

Unexpected role of the human cytomegalovirus contribute to essential hypertension in the Kazakh Chinese population of Xinjiang

Human cytomegalovirus (HCMV) infection, chronic inflammation and oxidative stress, the renin–angiotensin system (RAS), endothelial function, and DNA methylation play roles in the pathogenesis of essential hypertension (EH); however, the mechanism by which HCMV predisposes patients to hypertension re...

Descripción completa

Detalles Bibliográficos
Autores principales: Feng, Qian, Hui, Jing, Tang, Na, Liu, Yong-Min, Zhong, Hua, Li, Zhen, Wang, La-Mei, Qu, Yuan-Yuan, Deng, Feng-Mei, He, Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019381/
https://www.ncbi.nlm.nih.gov/pubmed/29752343
http://dx.doi.org/10.1042/BSR20171522
_version_ 1783335108811423744
author Feng, Qian
Hui, Jing
Tang, Na
Liu, Yong-Min
Zhong, Hua
Li, Zhen
Wang, La-Mei
Qu, Yuan-Yuan
Deng, Feng-Mei
He, Fang
author_facet Feng, Qian
Hui, Jing
Tang, Na
Liu, Yong-Min
Zhong, Hua
Li, Zhen
Wang, La-Mei
Qu, Yuan-Yuan
Deng, Feng-Mei
He, Fang
author_sort Feng, Qian
collection PubMed
description Human cytomegalovirus (HCMV) infection, chronic inflammation and oxidative stress, the renin–angiotensin system (RAS), endothelial function, and DNA methylation play roles in the pathogenesis of essential hypertension (EH); however, the mechanism by which HCMV predisposes patients to hypertension remain unclear. Our group previously demonstrated an association between EH and HCMV infection in Kazakh Chinese. Here, we investigated the relationship between HCMV infection and other clinicopathological features in 720 Kazakh individuals with or without hypertension (n=360 each; age: 18–80). Multiple linear and logistic regression analyses were used to determine the associations between HCMV infection, clinical characteristics, and EH. Notably, patients with EH, particularly those with HCMV infection, exhibited a marked increase in tumor necrosis factor-α (TNF-α) and 8-hydroxy-2-deoxyguanosine (8-OHDG) levels, but a decrease in endothelial nitric oxide synthase (eNOS) and renin levels. Similarly, elevated TNF-α and 8-OHDG levels were independent predictors of increased HCMV antibody titers, whereas eNOS and renin were negatively correlated with the latter. Moreover, serum angiotensin-converting enzyme (sACE, ACE) methylation was increased, whereas 11-β hydroxysteroid dehydrogenase 2 (HSD11β2; HSD3B2) methylation was decreased in patients with EH who were also infected with HCMV. A positive correlation between HSD3B2 methylation and HCMV IgG titer and blood pressure was additionally observed, whereas angiotensin-converting enzyme (ACE) methylation was inversely correlated with blood pressure. Collectively, these data indicate that HCMV may contribute to EH development in the Kazakh Chinese by increasing TNF-α and 8-OHDG levels, suppressing eNOS and renin, and manipulating HSD3B2 and ACE methylation.
format Online
Article
Text
id pubmed-6019381
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Portland Press Ltd.
record_format MEDLINE/PubMed
spelling pubmed-60193812018-07-05 Unexpected role of the human cytomegalovirus contribute to essential hypertension in the Kazakh Chinese population of Xinjiang Feng, Qian Hui, Jing Tang, Na Liu, Yong-Min Zhong, Hua Li, Zhen Wang, La-Mei Qu, Yuan-Yuan Deng, Feng-Mei He, Fang Biosci Rep Research Articles Human cytomegalovirus (HCMV) infection, chronic inflammation and oxidative stress, the renin–angiotensin system (RAS), endothelial function, and DNA methylation play roles in the pathogenesis of essential hypertension (EH); however, the mechanism by which HCMV predisposes patients to hypertension remain unclear. Our group previously demonstrated an association between EH and HCMV infection in Kazakh Chinese. Here, we investigated the relationship between HCMV infection and other clinicopathological features in 720 Kazakh individuals with or without hypertension (n=360 each; age: 18–80). Multiple linear and logistic regression analyses were used to determine the associations between HCMV infection, clinical characteristics, and EH. Notably, patients with EH, particularly those with HCMV infection, exhibited a marked increase in tumor necrosis factor-α (TNF-α) and 8-hydroxy-2-deoxyguanosine (8-OHDG) levels, but a decrease in endothelial nitric oxide synthase (eNOS) and renin levels. Similarly, elevated TNF-α and 8-OHDG levels were independent predictors of increased HCMV antibody titers, whereas eNOS and renin were negatively correlated with the latter. Moreover, serum angiotensin-converting enzyme (sACE, ACE) methylation was increased, whereas 11-β hydroxysteroid dehydrogenase 2 (HSD11β2; HSD3B2) methylation was decreased in patients with EH who were also infected with HCMV. A positive correlation between HSD3B2 methylation and HCMV IgG titer and blood pressure was additionally observed, whereas angiotensin-converting enzyme (ACE) methylation was inversely correlated with blood pressure. Collectively, these data indicate that HCMV may contribute to EH development in the Kazakh Chinese by increasing TNF-α and 8-OHDG levels, suppressing eNOS and renin, and manipulating HSD3B2 and ACE methylation. Portland Press Ltd. 2018-06-27 /pmc/articles/PMC6019381/ /pubmed/29752343 http://dx.doi.org/10.1042/BSR20171522 Text en © 2018 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Articles
Feng, Qian
Hui, Jing
Tang, Na
Liu, Yong-Min
Zhong, Hua
Li, Zhen
Wang, La-Mei
Qu, Yuan-Yuan
Deng, Feng-Mei
He, Fang
Unexpected role of the human cytomegalovirus contribute to essential hypertension in the Kazakh Chinese population of Xinjiang
title Unexpected role of the human cytomegalovirus contribute to essential hypertension in the Kazakh Chinese population of Xinjiang
title_full Unexpected role of the human cytomegalovirus contribute to essential hypertension in the Kazakh Chinese population of Xinjiang
title_fullStr Unexpected role of the human cytomegalovirus contribute to essential hypertension in the Kazakh Chinese population of Xinjiang
title_full_unstemmed Unexpected role of the human cytomegalovirus contribute to essential hypertension in the Kazakh Chinese population of Xinjiang
title_short Unexpected role of the human cytomegalovirus contribute to essential hypertension in the Kazakh Chinese population of Xinjiang
title_sort unexpected role of the human cytomegalovirus contribute to essential hypertension in the kazakh chinese population of xinjiang
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019381/
https://www.ncbi.nlm.nih.gov/pubmed/29752343
http://dx.doi.org/10.1042/BSR20171522
work_keys_str_mv AT fengqian unexpectedroleofthehumancytomegaloviruscontributetoessentialhypertensioninthekazakhchinesepopulationofxinjiang
AT huijing unexpectedroleofthehumancytomegaloviruscontributetoessentialhypertensioninthekazakhchinesepopulationofxinjiang
AT tangna unexpectedroleofthehumancytomegaloviruscontributetoessentialhypertensioninthekazakhchinesepopulationofxinjiang
AT liuyongmin unexpectedroleofthehumancytomegaloviruscontributetoessentialhypertensioninthekazakhchinesepopulationofxinjiang
AT zhonghua unexpectedroleofthehumancytomegaloviruscontributetoessentialhypertensioninthekazakhchinesepopulationofxinjiang
AT lizhen unexpectedroleofthehumancytomegaloviruscontributetoessentialhypertensioninthekazakhchinesepopulationofxinjiang
AT wanglamei unexpectedroleofthehumancytomegaloviruscontributetoessentialhypertensioninthekazakhchinesepopulationofxinjiang
AT quyuanyuan unexpectedroleofthehumancytomegaloviruscontributetoessentialhypertensioninthekazakhchinesepopulationofxinjiang
AT dengfengmei unexpectedroleofthehumancytomegaloviruscontributetoessentialhypertensioninthekazakhchinesepopulationofxinjiang
AT hefang unexpectedroleofthehumancytomegaloviruscontributetoessentialhypertensioninthekazakhchinesepopulationofxinjiang